How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer's disease risk? A novel integrative model.

de Frutos Lucas, Jaisalmer; Sewell, Kelsey R; García-Colomo, Alejandra; Markovic, Shaun; Erickson, Kirk I; Brown, Belinda M

de Frutos Lucas, Jaisalmer; Sewell, Kelsey R; García-Colomo, Alejandra; Markovic, Shaun; Erickson, Kirk I; Brown, Belinda M.

Afiliação

de Frutos Lucas J; Experimental Psychology, Cognitive Processes and Logopedia Department, School of Psychology, Universidad Complutense de Madrid, 28223, Pozuelo de Alarcón, Spain. jaidefru@ucm.es.
Sewell KR; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, 6027, Australia. jaidefru@ucm.es.
García-Colomo A; Departamento de PsicologíaFacultad de Ciencias de la Vida y de la Naturaleza, Universidad Antonio de Nebrija, 28015, Madrid, Spain. jaidefru@ucm.es.
Markovic S; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, 6150, Australia.
Erickson KI; Experimental Psychology, Cognitive Processes and Logopedia Department, School of Psychology, Universidad Complutense de Madrid, 28223, Pozuelo de Alarcón, Spain.
Brown BM; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, 6150, Australia.

Alzheimers Res Ther ; 15(1): 22, 2023 01 27.

Article em En | MEDLINE | ID: mdl-36707869

Assuntos

Doença de Alzheimer; Humanos; Doença de Alzheimer/genética; Doença de Alzheimer/patologia; Peptídeos beta-Amiloides/genética; Apolipoproteína E4/genética; Apolipoproteínas E/genética; Genótipo; Exercício Físico

Palavras-chave

APOE Îµ4; Alzheimer's disease; Amyloid pathology; Cerebrovascular health; Glucose metabolism; Mitochondrial dysfunction; Neuroinflammation; Neurotrophic factors; Physical activity; Tau pathology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Tipo de estudo: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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