Elimination of perineuronal nets in CA1 disrupts GABA release and long-term contextual fear memory retention.
Hippocampus
; 33(7): 862-871, 2023 Jul.
Article
em En
| MEDLINE
| ID: mdl-36709413
Perineuronal nets (PNNs) which mostly surround the parvalbumin (PV) neurons, have been shown to play critical roles in neural plasticity. Recently, PNNs have been shown to regulate fear-associated memory, but the molecular mechanism is still unclear. In this study, we found that removal of PNNs in vivo using chondroitinase ABC (ChABC) injection resulted in reduced firing rate of PV neurons and decreased inhibitory synaptic transmission in both PV neurons and excitatory neurons in the CA1 hippocampus. Interestingly, altered synaptic transmission appears to be mediated by presynaptic changes. Furthermore, ChABC treatment disrupts long-term contextual fear memory retention. These results suggest PNNs might alter fear memory by reducing the presynaptic GABA release.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Matriz Extracelular
/
Neurônios
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article