Your browser doesn't support javascript.
loading
HIV vaccine candidate efficacy in female macaques mediated by cAMP-dependent efferocytosis and V2-specific ADCC.
Bissa, Massimiliano; Kim, Sohyoung; Galli, Veronica; Fourati, Slim; Sarkis, Sarkis; Arakelyan, Anush; de Castro, Isabela Silva; Rahman, Mohammad Arif; Fujiwara, Saori; Vaccari, Monica; Tomalka, Jeffrey A; Stamos, James D; Schifanella, Luca; Gorini, Giacomo; Moles, Ramona; Gutowska, Anna; Ferrari, Guido; Lobanov, Alexei; Montefiori, David C; Nelson, George W; Cam, Margaret C; Chakhtoura, Marita; Haddad, Elias K; Doster, Melvin N; McKinnon, Katherine; Brown, Sophia; Venzon, David J; Choo-Wosoba, Hyoyoung; Breed, Matthew W; Killoran, Kristin E; Kramer, Joshua; Margolis, Leonid; Sekaly, Rafick P; Hager, Gordon L; Franchini, Genoveffa.
Afiliação
  • Bissa M; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA. massimiliano.bissa@nih.gov.
  • Kim S; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Galli V; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
  • Fourati S; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.
  • Sarkis S; Department of Pathology, Emory University, Atlanta, GA, USA.
  • Arakelyan A; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
  • de Castro IS; Section on Intercellular Interactions, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
  • Rahman MA; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
  • Fujiwara S; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
  • Vaccari M; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Tomalka JA; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
  • Stamos JD; Tulane National Primate Research Center, Tulane University, Covington, LA, USA.
  • Schifanella L; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.
  • Gorini G; Department of Pathology, Emory University, Atlanta, GA, USA.
  • Moles R; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
  • Gutowska A; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
  • Ferrari G; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
  • Lobanov A; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
  • Montefiori DC; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
  • Nelson GW; Division of Surgical Sciences, Duke University School of Medicine, Durham, NC, USA.
  • Cam MC; Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • Chakhtoura M; Division of Surgical Sciences, Duke University School of Medicine, Durham, NC, USA.
  • Haddad EK; Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • Doster MN; Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • McKinnon K; Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.
  • Brown S; Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.
  • Venzon DJ; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
  • Choo-Wosoba H; Vaccine Branch Flow Cytometry Core, National Cancer Institute, Bethesda, MD, USA.
  • Breed MW; Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA.
  • Killoran KE; Vaccine Branch Flow Cytometry Core, National Cancer Institute, Bethesda, MD, USA.
  • Kramer J; Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • Margolis L; Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • Sekaly RP; Laboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, MD, USA.
  • Hager GL; Laboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, MD, USA.
  • Franchini G; Laboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, MD, USA.
Nat Commun ; 14(1): 575, 2023 02 02.
Article em En | MEDLINE | ID: mdl-36732510
ABSTRACT
The development of an effective vaccine to protect against HIV acquisition will be greatly bolstered by in-depth understanding of the innate and adaptive responses to vaccination. We report here that the efficacy of DNA/ALVAC/gp120/alum vaccines, based on V2-specific antibodies mediating apoptosis of infected cells (V2-ADCC), is complemented by efferocytosis, a cyclic AMP (cAMP)-dependent antiphlogistic engulfment of apoptotic cells by CD14+ monocytes. Central to vaccine efficacy is the engagement of the CCL2/CCR2 axis and tolerogenic dendritic cells producing IL-10 (DC-10). Epigenetic reprogramming in CD14+ cells of the cyclic AMP/CREB pathway and increased systemic levels of miRNA-139-5p, a negative regulator of expression of the cAMP-specific phosphodiesterase PDE4D, correlated with vaccine efficacy. These data posit that efferocytosis, through the prompt and effective removal of apoptotic infected cells, contributes to vaccine efficacy by decreasing inflammation and maintaining tissue homeostasis.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Vacinas contra a AIDS Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Vacinas contra a AIDS Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article