A physiologically based pharmacokinetic model for [<sup>68</sup>Ga]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients.

Siebinga, Hinke; de Wit-van der Veen, Berlinda J; Beijnen, Jos H; Dorlo, Thomas P C; Huitema, Alwin D R; Hendrikx, Jeroen J M A

A physiologically based pharmacokinetic model for [⁶⁸Ga]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients.

Siebinga, Hinke; de Wit-van der Veen, Berlinda J; Beijnen, Jos H; Dorlo, Thomas P C; Huitema, Alwin D R; Hendrikx, Jeroen J M A.

Afiliação

Siebinga H; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. h.siebinga@nki.nl.
de Wit-van der Veen BJ; Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands. h.siebinga@nki.nl.
Beijnen JH; Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Dorlo TPC; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Huitema ADR; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Hendrikx JJMA; Department of Pharmacy, Uppsala University, Uppsala, Sweden.

EJNMMI Res ; 13(1): 8, 2023 Feb 03.

Article em En | MEDLINE | ID: mdl-36735114

Palavras-chave

68Ga-DOTATATE; 68Ga-HA-DOTATATE; PBPK; Tumor sink effect; Whole-body distribution

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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