TLR9 triggers MyD88-independent anti-inflammatory signaling in lupus.
Trends Immunol
; 44(3): 153-155, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-36740514
Activation of Toll-like receptor 7 (TLR7) can induce lupus in mice, whereas activation of TLR9 can prevent it, even though both receptors interact with myeloid differentiation primary response gene 88 (MyD88) for downstream signaling. How TLR9 triggers anti-inflammatory responses in autoimmunity is unclear. Leibler et al. recently reported that TLR9 initiates anti-inflammatory signaling and inhibits lupus pathogenesis in a MyD88-independent but ligand-dependent manner.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptor Toll-Like 9
/
Fator 88 de Diferenciação Mieloide
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article