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Physical and mental health status of former smokers and non-smokers patients with bipolar disorder.
Nobile, Bénédicte; Godin, Ophélia; Gard, Sébastien; Samalin, Ludovic; Brousse, Georges; Loftus, Joséphine; Aubin, Valérie; Belzeaux, Raoul; Dubertret, Caroline; Le Strat, Yann; Mazer, Nicolas; de Prémorel, Alix; Roux, Paul; Polosan, Mircea; Schwintzer, Thomas; Llorca, Pierre-Michel; Biseul, Isabelle; Etain, Bruno; Moirand, Remi; Olié, Emilie; Haffen, Emmanuel; Leboyer, Marion; Courtet, Philippe; Guillaume, Sébastien; Icick, Romain.
Afiliação
  • Nobile B; Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital CHU Montpellier, Montpellier, France.
  • Godin O; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.
  • Gard S; FondaMental Foundation, Créteil, France.
  • Samalin L; FondaMental Foundation, Créteil, France.
  • Brousse G; INSERM U955, Département Hospitalo-Universitaire de Psychiatrie et d'Addictologie des Hôpitaux Universitaires H Mondor, AP-HP, Université Paris-Est Créteil, Créteil, France.
  • Loftus J; FondaMental Foundation, Créteil, France.
  • Aubin V; Center Hospitalier Charles Perrens, France NutriNeuro, INRAE UMR 1286, University of Bordeaux, Pôle de Psychiatrie Générale et Universitaire, Bordeaux, France.
  • Belzeaux R; FondaMental Foundation, Créteil, France.
  • Dubertret C; CHU Clermont-Ferrand, Department of Psychiatry, University of Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, France.
  • Le Strat Y; FondaMental Foundation, Créteil, France.
  • Mazer N; CHU Clermont-Ferrand, Department of Psychiatry, University of Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, Clermont-Ferrand, France.
  • de Prémorel A; FondaMental Foundation, Créteil, France.
  • Roux P; Center Hospitalier Princesse Grace, Pôle de Psychiatrie, Monaco, Monaco.
  • Polosan M; FondaMental Foundation, Créteil, France.
  • Schwintzer T; Center Hospitalier Princesse Grace, Pôle de Psychiatrie, Monaco, Monaco.
  • Llorca PM; Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital CHU Montpellier, Montpellier, France.
  • Biseul I; Pôle de Psychiatrie, Assistance Publique Hôpitaux de Marseille, INT-UMR7289, CNRS Aix-Marseille Université, Marseille, France.
  • Etain B; FondaMental Foundation, Créteil, France.
  • Moirand R; INSERM UMR1266, AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, service de Psychiatrie et Addictologie, Hôpital Louis Mourier, Université de Paris, Colombes, France.
  • Olié E; FondaMental Foundation, Créteil, France.
  • Haffen E; INSERM UMR1266, AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, service de Psychiatrie et Addictologie, Hôpital Louis Mourier, Université de Paris, Colombes, France.
  • Leboyer M; FondaMental Foundation, Créteil, France.
  • Courtet P; INSERM UMR1266, AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, service de Psychiatrie et Addictologie, Hôpital Louis Mourier, Université de Paris, Colombes, France.
  • Guillaume S; FondaMental Foundation, Créteil, France.
  • Icick R; INSERM UMR1266, AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, service de Psychiatrie et Addictologie, Hôpital Louis Mourier, Université de Paris, Colombes, France.
Acta Psychiatr Scand ; 147(4): 373-388, 2023 04.
Article em En | MEDLINE | ID: mdl-36751870
ABSTRACT

OBJECTIVES:

Up to 70% individuals with bipolar disorder (BD) are lifetime tobacco smokers, a major modifiable risk factor for morbidity. However, quitting smoking is rarely proposed to individuals with BD, mainly because of fear of unfavorable metabolic or psychiatric changes. Evaluating the physical and mental impact of tobacco cessation is primordial. The aim of this study was to characterize the psychiatric and nonpsychiatric correlates of tobacco smoking status (never- vs. current vs. former smokers) in individuals with BD.

METHODS:

3860 individuals with ascertained BD recruited in the network of Fondamental expert centers for BD between 2009 and 2020 were categorized into current, former, and never tobacco smokers. We compared the sociodemographic and clinical characteristics assessed by standard instruments (e.g., BD type, current symptoms load, and non-psychiatric morbidity-including anthropometric and biological data) of the three groups using multinomial regression logistic models. Corrections for multiple testing were applied.

RESULTS:

Current smokers had higher depression, anxiety, and impulsivity levels than former and never-smokers, and also higher risk of comorbid substance use disorders with a gradient from never to former to current smokers-suggesting shared liability. Current smokers were at higher risk to have a metabolic syndrome than never-smokers, although this was only evidenced in cases, who were not using antipsychotics.

CONCLUSIONS:

Tobacco smoking was associated with high morbidity level. Strikingly, as in the general population, quitting smoking seemed associated with their return to the never-smokers' levels. Our findings strongly highlight the need to spread strategies to treat tobacco addiction in the BD population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Abandono do Hábito de Fumar Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Abandono do Hábito de Fumar Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article