Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the <i>MIR141/MIR200C</i>-ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cells.

Vad-Nielsen, Johan; Staunstrup, Nicklas Heine; Kjeldsen, Magnus Lindkvist; Dybdal, Nina; Flandin, Guillaume; De Stradis, Claudia; Daugaard, Tina Fuglsang; Vilsbøll-Larsen, Trine; Maansson, Christoffer Trier; Doktor, Thomas Koed; Sorensen, Boe Sandahl; Nielsen, Anders Lade

Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the MIR141/MIR200C-ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cells.

Vad-Nielsen, Johan; Staunstrup, Nicklas Heine; Kjeldsen, Magnus Lindkvist; Dybdal, Nina; Flandin, Guillaume; De Stradis, Claudia; Daugaard, Tina Fuglsang; Vilsbøll-Larsen, Trine; Maansson, Christoffer Trier; Doktor, Thomas Koed; Sorensen, Boe Sandahl; Nielsen, Anders Lade.

Afiliação

Vad-Nielsen J; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Staunstrup NH; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Kjeldsen ML; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Dybdal N; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Flandin G; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
De Stradis C; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Daugaard TF; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Vilsbøll-Larsen T; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Maansson CT; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Doktor TK; Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
Sorensen BS; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Nielsen AL; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark.

Transl Lung Cancer Res ; 12(1): 42-65, 2023 Jan 31.

Article em En | MEDLINE | ID: mdl-36762066

Palavras-chave

Non-small cell lung cancer (NSCLC); epigenetics; epithelial-mesenchymal-transition (EMT); tyrosine kinase inhibitor-resistance (TKI-resistance)

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google