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Trends in incidence, treatment and survival of Merkel cell carcinoma in England 2004-2018: a cohort study.
Mistry, Khaylen; Levell, Nick J; Hollestein, Loes; Wakkee, Marlies; Nijsten, Tamar; Knott, Craig S; Steven, Neil M; Craig, Paul J; Venables, Zoe C.
Afiliação
  • Mistry K; Department of Dermatology, Norfolk and Norwich University Hospital, Norwich, UK.
  • Levell NJ; Norwich Medical School, University of East Anglia, Norwich, UK.
  • Hollestein L; Department of Dermatology, Norfolk and Norwich University Hospital, Norwich, UK.
  • Wakkee M; Norwich Medical School, University of East Anglia, Norwich, UK.
  • Nijsten T; Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands.
  • Knott CS; Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands.
  • Steven NM; Erasmus MC Cancer Institute, University Medical Center, Rotterdam, the Netherlands.
  • Craig PJ; National Disease Registration Service, NHS Digital, Leeds, UK.
  • Venables ZC; Health Data Insight CIC, Cambridge, UK.
Br J Dermatol ; 188(2): 228-236, 2023 02 10.
Article em En | MEDLINE | ID: mdl-36763882
BACKGROUND: Merkel cell carcinoma (MCC) is a rare tumour with neuroendocrine differentiation and high associated mortality. Studies that describe the epidemiology of MCC are often limited by small sample size, short duration of follow-up, absence of nationwide data and paucity of data on different risk factors. OBJECTIVES: To determine the incidence, demographics and survival for MCC in England between 2004 and 2018. METHODS: This national retrospective cohort study identified all cases of MCC in England from 2004 to 2018 using national population-based data from the National Disease Registration Service. Crude counts, European age-standardized incidence rates (EASRs) and joinpoint analysis were conducted. Patient demographics and treatments received were described. Multivariable Cox regression analysis was used to study risk factors for MCC-specific mortality, by including a priori defined demographic factors, tumour characteristics and immunosuppression. Treatment data were not included in the Cox regression analysis. RESULTS: A total of 3775 MCC tumours were registered. The median age at diagnosis was 81 years (interquartile range 74-87). Overall, 96·6% of patients identified as White ethnicity, and 8·3% of patients were immunosuppressed. The most common site was the face (27·4%). Patients most often presented with stage one disease (22·8%); however, stage was unknown in 31·0%. In total, 80·7% of patients underwent surgical excision, 43·5% radiotherapy and 9·2% systemic therapy. The EASR increased from 0·43 per 100 000 person-years (PYs) to 0·65 per 100 000 person-years between 2004 and 2018, representing a significant annual percentage change of 3·9%. The EASR was greater in men than in women for all years, with an overall male-to-female ratio of 1·41 : 1. The highest EASR was in South West England. Five-year disease-specific survival was 65·6% [95% confidence interval (CI) 63·8-67·4], with a median follow-up of 767 days. MCC-specific mortality increased with age [hazard ratio (HR) 1·02, 95% CI 1·02-1·03], deprivation (HR 1·43, 95% CI 1·16-1·76), immunosuppression (HR 2·80, 95% CI 2·34-3·34) and stage at diagnosis (HR 8·24, 95% CI 5·84-11·6). CONCLUSIONS: This study presents the largest national MCC dataset in Europe, and the most complete reporting of MCC incidence and survival ever published. With the EASR of MCC increasing and high associated mortality, this study encourages further research into the pathology, diagnosis and therapeutic options for MCC to support management guidelines.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Carcinoma de Célula de Merkel Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Carcinoma de Célula de Merkel Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article