Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease.
Biochim Biophys Acta Mol Basis Dis
; 1869(4): 166660, 2023 04.
Article
em En
| MEDLINE
| ID: mdl-36764206
ABSTRACT
The cytoplasmic protein tumor progression locus 2 (TPL2), also known as cancer Osaka thyroid (Cot), or MAP3K8, is thought to have a significant role in a variety of cancers and illnesses and it is a key component in the activation pathway for the expression of inflammatory mediators. Despite the tight connection between inflammation and TPL2, its function has not been extensively studied in chronic liver disease (CLD), a major cause of morbidity and mortality worldwide. Here, we analyze more in detail the significance of TPL2 in CLD to shed light on the pathological and molecular transduction pattern of TPL2 during the progression of CLD. This might result in important advancements and enable progress in the diagnosis and treatment of CLD.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Glândula Tireoide
/
Hepatopatias
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article