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Risk of Cancer in Patients with Inflammatory Bowel Diseases and Keys for Patient Management.
Laredo, Viviana; García-Mateo, Sandra; Martínez-Domínguez, Samuel J; López de la Cruz, Julia; Gargallo-Puyuelo, Carla J; Gomollón, Fernando.
Afiliação
  • Laredo V; Department of Gastroenterology, Lozano Blesa University Hospital, 50009 Zaragoza, Spain.
  • García-Mateo S; Aragón Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.
  • Martínez-Domínguez SJ; School of Medicine, University of Zaragoza, 50009 Zaragoza, Spain.
  • López de la Cruz J; Department of Gastroenterology, Lozano Blesa University Hospital, 50009 Zaragoza, Spain.
  • Gargallo-Puyuelo CJ; Aragón Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.
  • Gomollón F; School of Medicine, University of Zaragoza, 50009 Zaragoza, Spain.
Cancers (Basel) ; 15(3)2023 Jan 31.
Article em En | MEDLINE | ID: mdl-36765829
Chronic inflammation in patients with Inflammatory Bowel Disease (IBD) leads to an increased risk of colorectal cancer, small bowel cancer, intestinal lymphoma and cholangiocarcinoma. However, treatments for IBD have also been associated with an increased risk of neoplasms. Patients receiving Thiopurines (TPs) have an increased risk of hematologic malignancies, non-melanoma skin cancer, urinary tract neoplasms and cervical cancer. Anti-TNFs have been associated with a higher risk of neoplasms, mainly lymphomas and melanomas; however, the data are controversial, and some recent studies do not confirm the association. Nevertheless, other biologic agents, such as ustekinumab and vedolizumab, have not shown an increased risk of any neoplasm to date. The risk of malignancies with tofacitinib exists, but its magnitude and relationship with previous treatment with TPs is not defined, so more studies from daily clinical practice are needed. Although biologic therapy seems to be safe for patients with current cancer or a prior history of cancer, as has been demonstrated in other chronic inflammatory conditions, prospective studies in this specific population are needed. Until that time, it is crucial to manage such conditions via the combined clinical expertise of the gastroenterologist and oncologist.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article