Transcriptomic and Functional Evidence That miRNA193a-3p Inhibits Lymphatic Endothelial Cell (LEC) and LEC + MCF-7 Spheroid Growth Directly and by Altering MCF-7 Secretome.

Azzarito, Giovanna; Henry, Margit; Rotshteyn, Tamara; Leeners, Brigitte; Dubey, Raghvendra K

Azzarito, Giovanna; Henry, Margit; Rotshteyn, Tamara; Leeners, Brigitte; Dubey, Raghvendra K.

Afiliação

Azzarito G; Department of Reproductive Endocrinology, University Hospital Zurich, 8952 Schlieren, Switzerland.
Henry M; Center for Physiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Rotshteyn T; Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
Leeners B; Center for Physiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Dubey RK; Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.

Cells ; 12(3)2023 01 21.

Article em En | MEDLINE | ID: mdl-36766731

Assuntos

Neoplasias da Mama; Transcriptoma; Feminino; Humanos; Neoplasias da Mama/patologia; Citocinas/metabolismo; Células Endoteliais/metabolismo; Estradiol/farmacologia; Estradiol/metabolismo; Perfilação da Expressão Gênica; Interferons/metabolismo; Células MCF-7; Proteínas Proto-Oncogênicas c-akt/metabolismo; Secretoma; Microambiente Tumoral

Palavras-chave

DRGs; MCF-7 cells; breast cancer; conditioned medium; lymphatic endothelial cells; miRNA; proliferation; secretome; spheroids; transcriptome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Transcriptoma Limite: Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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