Design, Synthesis, and Biological Evaluation of 3-Substituted-Indolin-2-One Derivatives as Potent Anti-Inflammatory Agents.

Kim, Sung Jin; Lee, Sang Hyuk; Lee, Heesu; Shin, Myoung-Sook; Lee, Jae Wook

Kim, Sung Jin; Lee, Sang Hyuk; Lee, Heesu; Shin, Myoung-Sook; Lee, Jae Wook.

Afiliação

Kim SJ; College of Korean Medicine, Gachon University, Seongnam-si 13120, Republic of Korea.
Lee SH; Natural Product Research Center, Korea Institute of Science and Technology (KIST), Gangneung-si 25451, Republic of Korea.
Lee H; Department of Anatomy, College of Dentistry, Gangneung Wonju National University (GWNU), Gangneung-si 25457, Republic of Korea.
Shin MS; College of Korean Medicine, Gachon University, Seongnam-si 13120, Republic of Korea.
Lee JW; Natural Product Research Center, Korea Institute of Science and Technology (KIST), Gangneung-si 25451, Republic of Korea.

Int J Mol Sci ; 24(3)2023 Jan 20.

Article em En | MEDLINE | ID: mdl-36768389

Assuntos

Interleucina-6; Fator de Necrose Tumoral alfa; Interleucina-6/genética; Interleucina-6/metabolismo; Fator de Necrose Tumoral alfa/genética; Fator de Necrose Tumoral alfa/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Macrófagos/metabolismo; Anti-Inflamatórios/farmacologia; Anti-Inflamatórios/metabolismo; NF-kappa B/metabolismo; RNA Mensageiro/metabolismo; Lipopolissacarídeos/farmacologia; Lipopolissacarídeos/metabolismo; Óxido Nítrico/metabolismo; Óxido Nítrico Sintase Tipo II/metabolismo

Palavras-chave

3-substituted-indolin-2-one derivatives; cytokines; inflammation; macrophages

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-6 / Fator de Necrose Tumoral alfa Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google