Discovery of Novel Thiazolidinedione-Derivatives with Multi-Modal Antidiabetic Activities In Vitro and In Silico.

Arineitwe, Charles; Oderinlo, Ogunyemi; Tukulula, Matshawandile; Khanye, Setshaba; Khathi, Andile; Sibiya, Ntethelelo

Arineitwe, Charles; Oderinlo, Ogunyemi; Tukulula, Matshawandile; Khanye, Setshaba; Khathi, Andile; Sibiya, Ntethelelo.

Afiliação

Arineitwe C; Pharmacology Division, Rhodes University, Grahamstown 6140, South Africa.
Oderinlo O; Department of Chemistry, Faculty of Science, Federal University, Otuoke Bayelsa 562103, Nigeria.
Tukulula M; School of Chemistry and Physics, College of Agriculture, Engineering Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
Khanye S; Pharmaceutical Chemistry Division, Faculty of Pharmacy, Rhodes University, Makhanda 6140, South Africa.
Khathi A; School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
Sibiya N; Pharmacology Division, Rhodes University, Grahamstown 6140, South Africa.

Int J Mol Sci ; 24(3)2023 Feb 03.

Article em En | MEDLINE | ID: mdl-36769344

Assuntos

Hipoglicemiantes; Tiazolidinedionas; Hipoglicemiantes/farmacologia; Hipoglicemiantes/química; Tiazolidinedionas/farmacologia; Tiazolidinedionas/química; Rosiglitazona/farmacologia; Glucose/metabolismo; PPAR gama/metabolismo; Simulação de Acoplamento Molecular

Palavras-chave

diabetes mellitus; pharmacological screening; synthesis; therapeutic targets; thiazolidinedione-derivatives

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazolidinedionas / Hipoglicemiantes Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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