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Therapeutic Potential of Extracts from Macaranga tanarius (MTE) in Diabetic Nephropathy.
Hsu, Yung-Chien; Chang, Cheng-Chih; Hsieh, Ching-Chuan; Shih, Ya-Hsueh; Chang, Hsiu-Ching; Lin, Chun-Liang.
Afiliação
  • Hsu YC; Department of Nephrology, Chang Gung Memorial Hospital, Chiayi 613, Taiwan.
  • Chang CC; Kidney and Diabetic Complications Research Team (KDCRT), Chang Gung Memorial Hospital, Chiayi 613, Taiwan.
  • Hsieh CC; Division of General Surgery, Chang Gung Memorial Hospital, Chiayi 613, Taiwan.
  • Shih YH; Division of General Surgery, Chang Gung Memorial Hospital, Chiayi 613, Taiwan.
  • Chang HC; Department of Nephrology, Chang Gung Memorial Hospital, Chiayi 613, Taiwan.
  • Lin CL; Kidney and Diabetic Complications Research Team (KDCRT), Chang Gung Memorial Hospital, Chiayi 613, Taiwan.
Plants (Basel) ; 12(3)2023 Feb 02.
Article em En | MEDLINE | ID: mdl-36771740
Diabetic nephropathy is a complication of diabetes that leads to end-stage kidney disease and is a major health burden worldwide. Prenylflavonoid compounds extracted from Macaranga tanarius (MTE) exhibit anti-inflammation, anti-oxidant, and anti-bacterial properties. However, the effects of these compounds on diabetic nephropathy remain unclear. The effects of MTE on diabetic nephropathy were investigated in vitro by using mouse renal mesangial cells and in vivo by using a db/db knockout mouse model. No overt alteration in proliferation was observed in mouse renal mesangial cells treated with 0-1 µg/mL MTE. Western blot analysis indicated that MTE dose-dependently attenuated the expression of fibronectin, α-smooth muscle actin, and collagen IV. Administration of MTE ameliorated renal albumin loss in db/db mice. Immunohistochemical staining revealed that MTE mitigated diabetes-induced fibronectin and collagen IV expression. Periodic acid-Schiff (PAS) and trichrome staining also showed that administration of MTE reduced the renal fibrosis phenomenon. MTE significantly ameliorated diabetes-induced nephropathy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article