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Helminth egg derivatives as proregenerative immunotherapies.
Maestas, David R; Chung, Liam; Han, Jin; Wang, Xiaokun; Sommerfeld, Sven D; Kelly, Sean H; Moore, Erika; Nguyen, Helen Hieu; Mejías, Joscelyn C; Peña, Alexis N; Zhang, Hong; Hooks, Joshua S T; Chin, Alexander F; Andorko, James I; Berlinicke, Cynthia A; Krishnan, Kavita; Choi, Younghwan; Anderson, Amy E; Mahatme, Ronak; Mejia, Christopher; Eric, Marie; Woo, JiWon; Ganguly, Sudipto; Zack, Donald J; Zhao, Liang; Pearce, Edward J; Housseau, Franck; Pardoll, Drew M; Elisseeff, Jennifer H.
Afiliação
  • Maestas DR; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Chung L; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Han J; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, School of Medicine, Baltimore, MD 21287.
  • Wang X; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Sommerfeld SD; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Kelly SH; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Moore E; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Nguyen HH; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Mejías JC; Materials Science and Engineering, University of Florida, Gainesville, FL 32611.
  • Peña AN; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Zhang H; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Hooks JST; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Chin AF; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Andorko JI; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Berlinicke CA; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Krishnan K; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Choi Y; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, School of Medicine, Baltimore, MD 21287.
  • Anderson AE; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Mahatme R; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Mejia C; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Eric M; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Woo J; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Ganguly S; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Zack DJ; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Zhao L; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21287.
  • Pearce EJ; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, School of Medicine, Baltimore, MD 21287.
  • Housseau F; Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
  • Pardoll DM; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
  • Elisseeff JH; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, School of Medicine, Baltimore, MD 21287.
Proc Natl Acad Sci U S A ; 120(8): e2211703120, 2023 02 21.
Article em En | MEDLINE | ID: mdl-36780522
The immune system is increasingly recognized as an important regulator of tissue repair. We developed a regenerative immunotherapy from the helminth Schistosoma mansoni soluble egg antigen (SEA) to stimulate production of interleukin (IL)-4 and other type 2-associated cytokines without negative infection-related sequelae. The regenerative SEA (rSEA) applied to a murine muscle injury induced accumulation of IL-4-expressing T helper cells, eosinophils, and regulatory T cells and decreased expression of IL-17A in gamma delta (γδ) T cells, resulting in improved repair and decreased fibrosis. Encapsulation and controlled release of rSEA in a hydrogel further enhanced type 2 immunity and larger volumes of tissue repair. The broad regenerative capacity of rSEA was validated in articular joint and corneal injury models. These results introduce a regenerative immunotherapy approach using natural helminth derivatives.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquistossomose mansoni Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquistossomose mansoni Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article