Application of CAR-T cell technology in autoimmune diseases and human immunodeficiency virus infection treatment.
J Gene Med
; 25(5): e3484, 2023 05.
Article
em En
| MEDLINE
| ID: mdl-36781390
Chimeric antigen receptor (CAR) T-cell therapy is an immunotherapy approach that has played a tremendous role in the battle against cancer for years. Since the CAR T lymphocytes are unrestricted-major histocompatibility complex T lymphocytes, they could identify more targets than natural T cells, resulting in practical and widespread functions. The good prospects of CAR T-cell therapy in oncology can be additionally applied to treat other diseases such as autoimmune and infectious diseases. CAR-T cell-derived immunotherapy for autoimmune disorders can be allocated to CAR-Tregs and chimeric autoantibody receptor T cells. Other generations of CARs target human immunodeficiency virus (HIV) proteins. In this review, we summarize CAR-T cell therapies in autoimmune disorders and HIV infection.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Infecções por HIV
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Receptores de Antígenos Quiméricos
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article