RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4.

Fang, Jie; Wu, Xiafei; He, Jie; Zhang, Hanwen; Chen, Xuyang; Zhang, Hua; Novakovic, Boris; Qi, Hongbo; Yu, Xinyang

Fang, Jie; Wu, Xiafei; He, Jie; Zhang, Hanwen; Chen, Xuyang; Zhang, Hua; Novakovic, Boris; Qi, Hongbo; Yu, Xinyang.

Afiliação

Fang J; The Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Rd., Chongqing, 400016, China.
Wu X; Chongqing Key Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, 400016, China.
He J; The Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Rd., Chongqing, 400016, China.
Zhang H; Chongqing Key Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, 400016, China.
Chen X; The Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Rd., Chongqing, 400016, China.
Zhang H; Chongqing Key Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, 400016, China.
Novakovic B; The Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Rd., Chongqing, 400016, China.
Qi H; Chongqing Key Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, 400016, China.
Yu X; The Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Rd., Chongqing, 400016, China.

Mol Med ; 29(1): 23, 2023 02 20.

Article em En | MEDLINE | ID: mdl-36803098

Assuntos

Diabetes Gestacional; Resistência à Insulina; Síndrome Metabólica; Animais; Feminino; Humanos; Camundongos; Gravidez; Claudina-4/metabolismo; Diabetes Gestacional/genética; Diabetes Gestacional/metabolismo; Fígado/metabolismo; Síndrome Metabólica/metabolismo; Metiltransferases/metabolismo; RNA/metabolismo; RNA Mensageiro/metabolismo; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo

Palavras-chave

CLDN4; Gestational diabetes mellitus (GDM); Metabolic syndrome; N6-methyladenosine (m6A); RBM15; RNA modifications

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Diabetes Gestacional / Síndrome Metabólica Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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