A small molecule potent IRAK4 inhibitor abrogates lipopolysaccharide-induced macrophage inflammation in-vitro and in-vivo.

Choudhary, Saynaz A; Patra, Debarun; Sinha, Archana; Mazumder, Sayani; Pant, Rajat; Chouhan, Raju; Jha, Anupam Nath; Prusty, Biswa Mohan; Manna, Debasis; Das, Sajal K; Tikoo, Kulbhushan; Pal, Durba; Dasgupta, Suman

Choudhary, Saynaz A; Patra, Debarun; Sinha, Archana; Mazumder, Sayani; Pant, Rajat; Chouhan, Raju; Jha, Anupam Nath; Prusty, Biswa Mohan; Manna, Debasis; Das, Sajal K; Tikoo, Kulbhushan; Pal, Durba; Dasgupta, Suman.

Afiliação

Choudhary SA; Metabolic Disease Biology Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, 784028, Assam, India.
Patra D; Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, 140001, Punjab, India.
Sinha A; Metabolic Disease Biology Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, 784028, Assam, India.
Mazumder S; Metabolic Disease Biology Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, 784028, Assam, India.
Pant R; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab, 160062, India.
Chouhan R; Department of Chemical Sciences, Tezpur University, Tezpur, 784028, Assam, India.
Jha AN; Computational Biophysics Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, 784028, Assam, India.
Prusty BM; Department of Chemistry, Indian Institute of Technology Guwahati, Assam, 781039, India.
Manna D; Department of Chemistry, Indian Institute of Technology Guwahati, Assam, 781039, India.
Das SK; Department of Chemical Sciences, Tezpur University, Tezpur, 784028, Assam, India.
Tikoo K; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab, 160062, India.
Pal D; Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, 140001, Punjab, India.
Dasgupta S; Metabolic Disease Biology Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, 784028, Assam, India. Electronic address: suman@tezu.ernet.in.

Eur J Pharmacol ; 944: 175593, 2023 Apr 05.

Article em En | MEDLINE | ID: mdl-36804543

Assuntos

Lipopolissacarídeos; NF-kappa B; Animais; Camundongos; Inflamação/metabolismo; Quinases Associadas a Receptores de Interleucina-1/metabolismo; Lipopolissacarídeos/metabolismo; Macrófagos/metabolismo; Fator 88 de Diferenciação Mieloide/metabolismo; NF-kappa B/metabolismo; Receptor 4 Toll-Like/metabolismo

Palavras-chave

IRAK4 inhibitor; Inflammation; Macrophages; Toll-like receptor 4 signaling; Vanillin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lipopolissacarídeos / NF-kappa B Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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