High­throughput screening identification of a small­molecule compound that induces ferroptosis and attenuates the invasion and migration of hepatocellular carcinoma cells by targeting the STAT3/GPX4 axis.

Huang, Qi; Li, Jing; Ma, Mengqing; Lv, Minling; Hu, Rui; Sun, Jialing; Zhong, Xin; Sun, Xinfeng; Feng, Wenxing; Ma, Wenfeng; Zhang, Wei; Zhan, Bolin; Han, Zhiyi; Zhou, Xiaozhou

Highthroughput screening identification of a smallmolecule compound that induces ferroptosis and attenuates the invasion and migration of hepatocellular carcinoma cells by targeting the STAT3/GPX4 axis.

Huang, Qi; Li, Jing; Ma, Mengqing; Lv, Minling; Hu, Rui; Sun, Jialing; Zhong, Xin; Sun, Xinfeng; Feng, Wenxing; Ma, Wenfeng; Zhang, Wei; Zhan, Bolin; Han, Zhiyi; Zhou, Xiaozhou.

Afiliação

Huang Q; Department of Liver Disease, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Li J; Department of Liver Disease, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Ma M; Department of Liver Disease, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Lv M; Department of Liver Disease, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Hu R; Department of Liver Disease, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Sun J; Department of Liver Disease, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Zhong X; Department of Liver Disease, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Sun X; Department of Liver Disease, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Feng W; Department of Liver Disease, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Ma W; Department of Liver Disease, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Zhang W; Department of Liver Disease, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Zhan B; Department of Liver Disease, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Han Z; Department of Liver Disease, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Zhou X; Department of Liver Disease, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.

Int J Oncol ; 62(3)2023 Mar.

Article em En | MEDLINE | ID: mdl-36825585

Assuntos

Carcinoma Hepatocelular; Ferroptose; Neoplasias Hepáticas; Humanos; Carcinoma Hepatocelular/genética; Neoplasias Hepáticas/genética; Ensaios de Triagem em Larga Escala; Fator de Transcrição STAT3/metabolismo; Simulação de Acoplamento Molecular; Linhagem Celular Tumoral; Apoptose

Palavras-chave

ferroptosis; glutathione peroxidase 4; hepatocellular carcinoma; polyphyllin VI; signal transducer and activator of transcription 3

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Ferroptose / Neoplasias Hepáticas Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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