Mechanisms of Glucocerebrosidase Dysfunction in Parkinson's Disease.
J Mol Biol
; 435(12): 168023, 2023 06 15.
Article
em En
| MEDLINE
| ID: mdl-36828270
ABSTRACT
Beta-glucocerebrosidase is a lysosomal hydrolase, encoded by GBA1 that represents the most common risk gene associated with Parkinson's disease (PD) and Lewy Body Dementia. Glucocerebrosidase dysfunction has been also observed in the absence of GBA1 mutations across different genetic and sporadic forms of PD and related disorders, suggesting a broader role of glucocerebrosidase in neurodegeneration. In this review, we highlight recent advances in mechanistic characterization of glucocerebrosidase function as the foundation for development of novel therapeutics targeting glucocerebrosidase in PD and related disorders.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Glucosilceramidase
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article