Urinary and Serum Concentration of Deoxynivalenol (DON) and DON Metabolites as an Indicator of DON Contamination in Swine Diets.
Toxins (Basel)
; 15(2)2023 02 02.
Article
em En
| MEDLINE
| ID: mdl-36828434
ABSTRACT
Pig health is impaired and growth performance is reduced when exposed to deoxynivalenol (DON). The measurement of DON in individual feedstuffs and complete swine diets is variable because of the inconsistent distribution of mycotoxins in feed and the difficulties in obtaining representative samples. We investigated whether measuring DON and its metabolites in biological samples could be used as a predictor of DON ingestion by pigs. Blood samples were collected between 3 and 4 h after the morning meal and urine samples were quantitatively collected over a 24 h period on d 40 and 82 of the study to evaluate serum and urinary content of DON and DON metabolites (iso-deoxynivalenol, DON-3-glucuronide, DON-15-glcurunide, deepoxy-deoxynivalenol, iso-deepoxy-deoxynivalenol, deepoxy-deoxynivalenol-3-glucuronide, and deepoxy-deoxynivalenol-15-glucuronide). The intake of DON was positively correlated with urinary DON output. Similarly, there was an increase in serum DON level with increasing DON intake. Overall, it was found that DON intake correlated with DON concentration in urine and blood serum when samples were collected under controlled conditions. Analyzing DON levels in urine and blood serum could be used to predict a pig's DON intake.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tricotecenos
/
Micotoxinas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article