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Pharmaco-Toxicological Effects of Atypical Synthetic Cathinone Mephtetramine (MTTA) in Mice: Possible Reasons for Its Brief Appearance over NPSs Scene.
Corli, Giorgia; Tirri, Micaela; Arfè, Raffaella; Marchetti, Beatrice; Bernardi, Tatiana; Borsari, Martina; Odoardi, Sara; Mestria, Serena; Strano-Rossi, Sabina; Neri, Margherita; Gaudio, Rosa Maria; Bilel, Sabrine; Marti, Matteo.
Afiliação
  • Corli G; Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy.
  • Tirri M; Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy.
  • Arfè R; Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy.
  • Marchetti B; Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy.
  • Bernardi T; Department of Environmental Sciences and Prevention, University of Ferrara, 44121 Ferrara, Italy.
  • Borsari M; Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy.
  • Odoardi S; Forensic Toxicology Laboratory, Department of Health Surveillance and Bioethics, Università Cattolica del Sacro Cuore F. Policlinico Gemelli IRCCS, 00169 Rome, Italy.
  • Mestria S; Forensic Toxicology Laboratory, Department of Health Surveillance and Bioethics, Università Cattolica del Sacro Cuore F. Policlinico Gemelli IRCCS, 00169 Rome, Italy.
  • Strano-Rossi S; Forensic Toxicology Laboratory, Department of Health Surveillance and Bioethics, Università Cattolica del Sacro Cuore F. Policlinico Gemelli IRCCS, 00169 Rome, Italy.
  • Neri M; Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
  • Gaudio RM; Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy.
  • Bilel S; University Center for Studies on Gender Medicine, University of Ferrara, 44121 Ferrara, Italy.
  • Marti M; Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy.
Brain Sci ; 13(2)2023 Jan 18.
Article em En | MEDLINE | ID: mdl-36831704
Over the last year, NPSs have been steadily on the rise in the illicit drug market. Among these, synthetic cathinones seem to become increasingly popular among young adults, mainly because of their ability to replicate the effects of traditional psychostimulant drugs, such as cocaine, MDMA and amphetamines. However, scarce data are available about the in vivo pharmaco-toxicology of these new substances. To this end, this study focused on evaluation of effects induced by repeated administration of mephtetramine (MTTA 0.1-30 mg/kg i.p.) in mice. This atypical cathinone highlighted a sensorial (inhibition of visual and acoustic reflexes) and transient physiological parameter (decrease in breath rate and temperature) change in mice. Regarding motor activity, both a dose-dependent increase (accelerod test) and biphasic effect (drag and mobility time test) have been shown. In addition, blood and urine samples have been analysed to enrich the experimental featuring of the present study with reference to evaluation of potential toxicity related to consumption of MTTA. The latter analysis has particularly revealed important changes in blood cells count and blood and urine physicochemical profile after repeated treatment with this atypical cathinone. Moreover, MTTA induced histological changes in heart, kidney and liver samples, emphasizing its potential toxicity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article