Phospholipase D1 Attenuation Therapeutics Promotes Resilience against Synaptotoxicity in 12-Month-Old 3xTg-AD Mouse Model of Progressive Neurodegeneration.

Natarajan, Chandramouli; Cook, Charles; Ramaswamy, Karthik; Krishnan, Balaji

Natarajan, Chandramouli; Cook, Charles; Ramaswamy, Karthik; Krishnan, Balaji.

Afiliação

Natarajan C; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-1045, USA.
Cook C; Graduate School of Biomedical Sciences, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-1045, USA.
Ramaswamy K; School of Medicine, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-1045, USA.
Krishnan B; School of Medicine, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-1045, USA.

Int J Mol Sci ; 24(4)2023 Feb 08.

Article em En | MEDLINE | ID: mdl-36834781

Assuntos

Doença de Alzheimer; Disfunção Cognitiva; Camundongos; Humanos; Animais; Lactente; Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/metabolismo; Proteínas tau/metabolismo; Camundongos Transgênicos; Disfunção Cognitiva/patologia; Modelos Animais de Doenças; Precursor de Proteína beta-Amiloide/metabolismo; Mamíferos/metabolismo

Palavras-chave

Alzheimer's disease; cognitive deficit; dyslipidemia; excitability; neurodegeneration; phospholipase D; synaptic homeostasis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Infant Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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