Increased Expression of Hepatic Stearoyl-CoA Desaturase (SCD)-1 and Depletion of Eicosapentaenoic Acid (EPA) Content following Cytotoxic Cancer Therapy Are Reversed by Dietary Fish Oil.

Monirujjaman, Md; Renani, Leila Baghersad; Isesele, Peter; Dunichand-Hoedl, Abha R; Mazurak, Vera C

Monirujjaman, Md; Renani, Leila Baghersad; Isesele, Peter; Dunichand-Hoedl, Abha R; Mazurak, Vera C.

Afiliação

Monirujjaman M; Division of Human Nutrition, Department of Agricultural Food and Nutritional Science, Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB T6G 2P5, Canada.
Renani LB; Division of Human Nutrition, Department of Agricultural Food and Nutritional Science, Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB T6G 2P5, Canada.
Isesele P; Division of Human Nutrition, Department of Agricultural Food and Nutritional Science, Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB T6G 2P5, Canada.
Dunichand-Hoedl AR; Division of Human Nutrition, Department of Agricultural Food and Nutritional Science, Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB T6G 2P5, Canada.
Mazurak VC; Division of Human Nutrition, Department of Agricultural Food and Nutritional Science, Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB T6G 2P5, Canada.

Int J Mol Sci ; 24(4)2023 Feb 10.

Article em En | MEDLINE | ID: mdl-36834959

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica; Ácido Eicosapentaenoico; Óleos de Peixe; Neoplasias; Estearoil-CoA Dessaturase; Animais; Feminino; Ratos; Ácidos Docosa-Hexaenoicos/metabolismo; Ácido Eicosapentaenoico/metabolismo; Ácidos Graxos/metabolismo; Óleos de Peixe/farmacologia; Interleucina-4/metabolismo; Leptina/metabolismo; Fígado/metabolismo; Neoplasias/metabolismo; Estearoil-CoA Dessaturase/metabolismo; Triglicerídeos/metabolismo; Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem; Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Fígado Gorduroso/induzido quimicamente; Fígado Gorduroso/metabolismo; Irinotecano/efeitos adversos; Irinotecano/toxicidade; Fluoruracila/efeitos adversos; Fluoruracila/toxicidade

Palavras-chave

5-FU; CASSH; chemotherapy; colorectal cancer; fatty liver; irinotecan; n-3 PUFA; tumor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estearoil-CoA Dessaturase / Óleos de Peixe / Protocolos de Quimioterapia Combinada Antineoplásica / Ácido Eicosapentaenoico / Neoplasias Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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