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Longitudinal Changes in BDNF and MMP-9 Protein Plasma Levels in Children after Cochlear Implantation.
Matusiak, Monika; Ozieblo, Dominika; Oldak, Monika; Rejmak, Emilia; Kaczmarek, Leszek; Skarzynski, Henryk.
Afiliação
  • Matusiak M; Oto-Rhino-Laryngosurgery Clinic, Institute of Physiology and Pathology of Hearing, M Mochnackiego 10, 02-042 Warsaw, Poland.
  • Ozieblo D; World Hearing Centre, Mokra 17, 05-830 Nadarzyn, Poland.
  • Oldak M; World Hearing Centre, Mokra 17, 05-830 Nadarzyn, Poland.
  • Rejmak E; Department of Genetics, Institute of Physiology and Pathology of Hearing, M Mochnackiego 10, 02-042 Warsaw, Poland.
  • Kaczmarek L; World Hearing Centre, Mokra 17, 05-830 Nadarzyn, Poland.
  • Skarzynski H; Department of Genetics, Institute of Physiology and Pathology of Hearing, M Mochnackiego 10, 02-042 Warsaw, Poland.
Int J Mol Sci ; 24(4)2023 Feb 13.
Article em En | MEDLINE | ID: mdl-36835126
Congenitally deaf children who undergo cochlear implantation before 1 year of age develop their auditory skills faster than children who are implanted later. In this longitudinal study, a cohort of 59 implanted children were divided into two subgroups according to their ages at implantation-below or above 1 year old-and the plasma levels of matrix metalloproteinase-9 (MMP-9), brain-derived neurotrophic factor (BDNF), and pro-BDNF were measured at 0, 8, and 18 months after cochlear implant activation, while auditory development was simultaneously evaluated using the LittlEARs Questionnaire (LEAQ). A control group consisted of 49 age-matched healthy children. We identified statistically higher BDNF levels at 0 months and at the 18-month follow-ups in the younger subgroup compared to the older one and lower LEAQ scores at 0 months in the younger subgroup. Between the subgroups, there were significant differences in the changes in BDNF levels from 0 to 8 months and in LEAQ scores from 0 to 18 months. The MMP-9 levels significantly decreased from 0 to 18 months and from 0 to 8 months in both subgroups and from 8 to 18 months only in the older one. For all measured protein concentrations, significant differences were identified between the older study subgroup and the age-matched control group.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Neurotrófico Derivado do Encéfalo / Implante Coclear / Metaloproteinase 9 da Matriz / Surdez Tipo de estudo: Observational_studies / Prognostic_studies Limite: Child / Humans / Infant Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Neurotrófico Derivado do Encéfalo / Implante Coclear / Metaloproteinase 9 da Matriz / Surdez Tipo de estudo: Observational_studies / Prognostic_studies Limite: Child / Humans / Infant Idioma: En Ano de publicação: 2023 Tipo de documento: Article