Inhibition of Xanthine Oxidase Protects against Diabetic Kidney Disease through the Amelioration of Oxidative Stress via VEGF/VEGFR Axis and NOX-FoxO3a-eNOS Signaling Pathway.

Yang, Keum-Jin; Choi, Won Jung; Chang, Yoon-Kyung; Park, Cheol Whee; Kim, Suk Young; Hong, Yu Ah

Yang, Keum-Jin; Choi, Won Jung; Chang, Yoon-Kyung; Park, Cheol Whee; Kim, Suk Young; Hong, Yu Ah.

Afiliação

Yang KJ; Clinical Research Institute, Daejeon St. Mary's Hospital, 64, Daeheung-ro, Jung-gu, Daejeon 34943, Republic of Korea.
Choi WJ; Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.
Chang YK; Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.
Park CW; Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.
Kim SY; Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.
Hong YA; Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.

Int J Mol Sci ; 24(4)2023 Feb 14.

Article em En | MEDLINE | ID: mdl-36835220

Assuntos

Nefropatias Diabéticas; Xantina Oxidase; Animais; Humanos; Masculino; Camundongos; Nefropatias Diabéticas/tratamento farmacológico; Nefropatias Diabéticas/enzimologia; Células Endoteliais/metabolismo; Febuxostat/farmacologia; Camundongos Endogâmicos C57BL; NADPH Oxidases/metabolismo; Óxido Nítrico Sintase Tipo III/metabolismo; Estresse Oxidativo; RNA Mensageiro/metabolismo; Transdução de Sinais; Ácido Úrico/farmacologia; Fator A de Crescimento do Endotélio Vascular/metabolismo; Fatores de Crescimento do Endotélio Vascular/metabolismo; Xantina Oxidase/antagonistas & inibidores

Palavras-chave

NADPH oxidase; VEGF; diabetic kidney disease; oxidative stress; xanthine oxidase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Xantina Oxidase / Nefropatias Diabéticas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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