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Inhibition by pesticides of the DJ-1/Park7 protein related to Parkinson disease.
Mathas, Nicolas; Poncet, Gabrielle; Laurent, Catherine; Larigot, Lucie; Le-Grand, Béatrice; Gonis, Elodie; Birman, Serge; Galardon, Erwan; Sari, Marie-Agnès; Tiouaini, Mounira; Nioche, Pierre; Barouki, Robert; Coumoul, Xavier; Mansuy, Daniel; Dairou, Julien.
Afiliação
  • Mathas N; Université Paris cité, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, 45 rue des Saints Pères, F-75006 Paris, France.
  • Poncet G; Université Paris cité, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, 45 rue des Saints Pères, F-75006 Paris, France.
  • Laurent C; Université Paris cité, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, 45 rue des Saints Pères, F-75006 Paris, France.
  • Larigot L; Université Paris Cité, 45 rue des Saints Pères, F-75006 Paris, France; INSERM, UMR-S1124, T3S, 45 rue des Saints Pères, F-75006 Paris, France.
  • Le-Grand B; Université Paris Cité, 45 rue des Saints Pères, F-75006 Paris, France; INSERM, UMR-S1124, T3S, 45 rue des Saints Pères, F-75006 Paris, France.
  • Gonis E; Université Paris cité, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, 45 rue des Saints Pères, F-75006 Paris, France; Genes Circuits Rhythms and Neuropathology, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, Paris, France.
  • Birman S; Genes Circuits Rhythms and Neuropathology, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, Paris, France.
  • Galardon E; Université Paris cité, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, 45 rue des Saints Pères, F-75006 Paris, France.
  • Sari MA; Université Paris cité, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, 45 rue des Saints Pères, F-75006 Paris, France.
  • Tiouaini M; Université Paris Cité, 45 rue des Saints Pères, F-75006 Paris, France; INSERM, UMR-S1124, T3S, 45 rue des Saints Pères, F-75006 Paris, France; Structural and Molecular Analysis Platform, BioMedTech Facilities INSERM US36-CNRS UMS2009, Université Paris Cité, Paris, France.
  • Nioche P; Université Paris Cité, 45 rue des Saints Pères, F-75006 Paris, France; INSERM, UMR-S1124, T3S, 45 rue des Saints Pères, F-75006 Paris, France; Structural and Molecular Analysis Platform, BioMedTech Facilities INSERM US36-CNRS UMS2009, Université Paris Cité, Paris, France.
  • Barouki R; Université Paris Cité, 45 rue des Saints Pères, F-75006 Paris, France; INSERM, UMR-S1124, T3S, 45 rue des Saints Pères, F-75006 Paris, France.
  • Coumoul X; Université Paris Cité, 45 rue des Saints Pères, F-75006 Paris, France; INSERM, UMR-S1124, T3S, 45 rue des Saints Pères, F-75006 Paris, France.
  • Mansuy D; Université Paris cité, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, 45 rue des Saints Pères, F-75006 Paris, France.
  • Dairou J; Université Paris cité, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, 45 rue des Saints Pères, F-75006 Paris, France. Electronic address: julien.dairou@u-paris.fr.
Toxicology ; 487: 153467, 2023 03 15.
Article em En | MEDLINE | ID: mdl-36842454
ABSTRACT
Parkinson's disease is a severe neurodegenerative disease. Several environmental contaminants such as pesticides have been suspected to favor the appearance of this pathology. The protein DJ-1 (or Park7) protects against the development of Parkinson's disease. Thus, the possible inhibitory effects of about a hundred pesticides on human DJ-1 have been studied. We identified fifteen of them as strong inhibitors of DJ-1 with IC50 values between 0.02 and 30 µM. Thiocarbamates are particularly good inhibitors, as shown by thiram that acts as an irreversible inhibitor of an esterase activity of DJ-1 with an IC50 value of 0.02 µM. Thiram was also found as a good inhibitor of the protective activity of DJ-1 against glycation. Such inhibitory effects could be one of the various biological effects of these pesticides that may explain their involvement in the development of Parkinson's disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Praguicidas / Doenças Neurodegenerativas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Praguicidas / Doenças Neurodegenerativas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article