Prevalence of orofacial alterations in patients with sickle-cell disease: Systematic review and meta-analysis.
Oral Surg Oral Med Oral Pathol Oral Radiol
; 135(5): 642-660, 2023 05.
Article
em En
| MEDLINE
| ID: mdl-36858858
ABSTRACT
OBJECTIVE:
The aim of this study was to identify the prevalence of orofacial alterations in sickle-cell disease (SCD) and to compare it with the general population. STUDYDESIGN:
This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. The search was conducted on PubMed, Embase, Scientific Electronic Library Online, Web of Science, Cochrane Library, gray literature, and references of the included articles.RESULTS:
A total of 770 records were found, and 28 studies were selected. In SCD, the prevalence of decreased bone density was 57% (95% CI 35%-80%), with Q P < .01 and I2 = 95%; for stepladder pattern was 30% (IC 13%-47%), Q P < .01 and I² 93%; for delayed eruption was 20% (95% CI 6%-34%), with Q P < .01 and I2 = 86, Q P < .01 and I2 = 99%; and for malocclusion, 66% (95% CI 39%-92%), Q P < .01 and I2 = 98%. A high risk of bias was observed in relation to the sample size of the studies. A limited number of articles compared the prevalence of orofacial alterations in patients with SCD and healthy individuals.CONCLUSIONS:
Decreased bone density, malocclusion, orofacial pain, tooth necrosis, eruption delay, periodontal disease, and neuropathies may be present in patients with SCD with variable prevalence.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anemia Falciforme
/
Má Oclusão
Tipo de estudo:
Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article