Product-driven high-throughput screening of industrial filamentous actinomycetes.

Zhang, Yue; Zhang, Xuemei; Wang, Meng

Zhang, Yue; Zhang, Xuemei; Wang, Meng.

Afiliação

Zhang Y; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China. Electronic address: zhangy@tib.cas.cn.
Zhang X; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; Haihe Laboratory of Synthetic Biology, Tianjin 300308, China; School of Life Sciences, University of Science and Technology of China, Hefei 230026, China.
Wang M; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China. Electronic address: wangmeng@tib.cas.cn.

Trends Biotechnol ; 41(9): 1109-1112, 2023 09.

Article em En | MEDLINE | ID: mdl-36863908

ABSTRACT

ABSTRACT

Traditional strain breeding of industrial filamentous actinomycetes has long been hampered by insufficient screening throughput. From microtiter plate based methods to droplet-based microfluidic screening, various novel product-driven high-throughput screening (HTS) methods have pushed the screening speed limit towards a minimum of hundreds of strains per second with single cell resolution.

Assuntos

Actinobacteria; Actinomyces; Ensaios de Triagem em Larga Escala; Microfluídica; Reatores Biológicos

Palavras-chave

filamentous actinomycete; high productivity; high-throughput screening; product-driven; strain engineering

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Actinobacteria Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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