Hidden tricks in MATH: Hypermorphic mutations in SPOP tumor suppressor explained by cryo-EM.
Mol Cell
; 83(5): 655-656, 2023 03 02.
Article
em En
| MEDLINE
| ID: mdl-36868187
ABSTRACT
Loss-of-function mutations in SPOP E3 ubiquitin ligase drive multiple cancers. However, carcinogenic gain-of-function SPOP mutations have been a major puzzle. In this issue of Molecular Cell, Cuneo et al.1 show that several mutations map to SPOP oligomerization interfaces. Additional questions remain about SPOP mutations in malignancy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Proteínas Nucleares
/
Carcinógenos
/
Carcinogênese
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article