Lead exposure induced developmental nephrotoxicity in Japanese quail (Coturnix japonica) via oxidative stress-based PI3K/AKT pathway inhibition and NF-&#954;B pathway activation.

Zhang, Gaixia; Zhang, Yuxin; Jing, Lingyang; Zhao, Hongfeng

Lead exposure induced developmental nephrotoxicity in Japanese quail (Coturnix japonica) via oxidative stress-based PI3K/AKT pathway inhibition and NF-κB pathway activation.

Zhang, Gaixia; Zhang, Yuxin; Jing, Lingyang; Zhao, Hongfeng.

Afiliação

Zhang G; College of Life Sciences, Shaanxi Normal University, Xi'an 710119, China.
Zhang Y; College of Life Sciences, Shaanxi Normal University, Xi'an 710119, China.
Jing L; College of Life Sciences, Shaanxi Normal University, Xi'an 710119, China.
Zhao H; College of Life Sciences, Shaanxi Normal University, Xi'an 710119, China. Electronic address: zhaohf@snnu.edu.cn.

Comp Biochem Physiol C Toxicol Pharmacol ; 268: 109599, 2023 Jun.

Article em En | MEDLINE | ID: mdl-36893933

Assuntos

Coturnix; NF-kappa B; Animais; NF-kappa B/metabolismo; Coturnix/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Chumbo/toxicidade; Fosfatidilinositol 3-Quinase/metabolismo; Ácido Úrico/metabolismo; Ácido Úrico/farmacologia; Estresse Oxidativo; Inflamação

Palavras-chave

Apoptosis; Kidney; Oxidative stress; Pb; Transcriptomics; Uric acid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Coturnix Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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