HLA-B*57:01/Carbamazepine-10,11-Epoxide Association Triggers Upregulation of the NF&#954;B and JAK/STAT Pathways.

Haukamp, Funmilola Josephine; Hartmann, Zoe Maria; Pich, Andreas; Kuhn, Joachim; Blasczyk, Rainer; Stieglitz, Florian; Bade-Döding, Christina

HLA-B*57:01/Carbamazepine-10,11-Epoxide Association Triggers Upregulation of the NFκB and JAK/STAT Pathways.

Haukamp, Funmilola Josephine; Hartmann, Zoe Maria; Pich, Andreas; Kuhn, Joachim; Blasczyk, Rainer; Stieglitz, Florian; Bade-Döding, Christina.

Afiliação

Haukamp FJ; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Hartmann ZM; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Pich A; Institute of Toxicology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Kuhn J; Core Facility Proteomics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Blasczyk R; Institute for Laboratory and Transfusion Medicine, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Georgstraße 11, 32545 Bad Oeynhausen, Germany.
Stieglitz F; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Bade-Döding C; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Cells ; 12(5)2023 02 21.

Article em En | MEDLINE | ID: mdl-36899812

Assuntos

Hipersensibilidade a Drogas; Síndrome de Stevens-Johnson; Humanos; Janus Quinases; Anticonvulsivantes/uso terapêutico; Regulação para Cima; Proteômica; Fatores de Transcrição STAT/genética; Transdução de Sinais; Carbamazepina; Antígenos HLA-B/genética; Síndrome de Stevens-Johnson/etiologia; Síndrome de Stevens-Johnson/genética; NF-kappa B/genética

Palavras-chave

HLA; HLA-B*57:01; adverse drug reaction; carbamazepine; carbamazepine hypersensitivity; carbamazepine-10,11-epoxide; proteome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Stevens-Johnson / Hipersensibilidade a Drogas Tipo de estudo: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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