Simple In Vitro <sup>18</sup>O Labeling for Improved Mass Spectrometry-Based Drug Metabolites Identification: Deep Drug Metabolism Study.

Tupertsev, Boris; Osipenko, Sergey; Kireev, Albert; Nikolaev, Eugene; Kostyukevich, Yury

Simple In Vitro ¹⁸O Labeling for Improved Mass Spectrometry-Based Drug Metabolites Identification: Deep Drug Metabolism Study.

Tupertsev, Boris; Osipenko, Sergey; Kireev, Albert; Nikolaev, Eugene; Kostyukevich, Yury.

Afiliação

Tupertsev B; Center of Molecular and Cellular Biology (CMCB), Skolkovo Institute of Science and Technology, Nobel Str., 3, 121205 Moscow, Russia.
Osipenko S; Moscow Institute of Physics and Technology, Phystech School of Biological and Medical Physics, Institutskiy per., 9, Dolgoprudny, 141701 Moscow, Russia.
Kireev A; Center for Computational and Data-Intensive Science and Engineering, Skolkovo Institute of Science and Technology, Nobel Str., 3, 121205 Moscow, Russia.
Nikolaev E; Center of Molecular and Cellular Biology (CMCB), Skolkovo Institute of Science and Technology, Nobel Str., 3, 121205 Moscow, Russia.
Kostyukevich Y; Center of Molecular and Cellular Biology (CMCB), Skolkovo Institute of Science and Technology, Nobel Str., 3, 121205 Moscow, Russia.

Int J Mol Sci ; 24(5)2023 Feb 26.

Article em En | MEDLINE | ID: mdl-36902002

Assuntos

Microssomos Hepáticos; Espectrometria de Massas/métodos; Cromatografia Líquida de Alta Pressão; Microssomos Hepáticos/metabolismo; Marcação por Isótopo/métodos

Palavras-chave

18O; drug metabolism; mass spectrometry; metabolites identification

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microssomos Hepáticos Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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