Macrophage Polarization: An Important Candidate Regulator for Lung Diseases.
Molecules
; 28(5)2023 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-36903624
ABSTRACT
Macrophages are crucial components of the immune system and play a critical role in the initial defense against pathogens. They are highly heterogeneous and plastic and can be polarized into classically activated macrophages (M1) or selectively activated macrophages (M2) in response to local microenvironments. Macrophage polarization involves the regulation of multiple signaling pathways and transcription factors. Here, we focused on the origin of macrophages, the phenotype and polarization of macrophages, as well as the signaling pathways associated with macrophage polarization. We also highlighted the role of macrophage polarization in lung diseases. We intend to enhance the understanding of the functions and immunomodulatory features of macrophages. Based on our review, we believe that targeting macrophage phenotypes is a viable and promising strategy for treating lung diseases.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumopatias
/
Macrófagos
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article