Common framework mutations impact antibody interfacial dynamics and flexibility.

Rhodes, Emily R; Faris, Jonathan G; Petersen, Brian M; Sprenger, Kayla G

Rhodes, Emily R; Faris, Jonathan G; Petersen, Brian M; Sprenger, Kayla G.

Afiliação

Rhodes ER; Department of Chemical & Biological Engineering, University of Colorado, Boulder, CO, United States.
Faris JG; Department of Chemical & Biological Engineering, University of Colorado, Boulder, CO, United States.
Petersen BM; Department of Chemical & Biological Engineering, University of Colorado, Boulder, CO, United States.
Sprenger KG; Department of Chemical & Biological Engineering, University of Colorado, Boulder, CO, United States.

Front Immunol ; 14: 1120582, 2023.

Article em En | MEDLINE | ID: mdl-36911727

Assuntos

Cadeias Pesadas de Imunoglobulinas; Cadeias Leves de Imunoglobulina; Cadeias Pesadas de Imunoglobulinas/genética; Cadeias Leves de Imunoglobulina/genética; Mutação; Anticorpos/genética; Solventes

Palavras-chave

antibodies; antibody interfacial dynamics; flexibility; framework mutations; molecular dynamics simulations (MD)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cadeias Pesadas de Imunoglobulinas / Cadeias Leves de Imunoglobulina Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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