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Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations.
Hirayama, Tatsuro; Miyazaki, Taiga; Sumiyoshi, Makoto; Ito, Yuya; Ashizawa, Nobuyuki; Takeda, Kazuaki; Iwanaga, Naoki; Takazono, Takahiro; Yamamoto, Kazuko; Izumikawa, Koichi; Yanagihara, Katsunori; Makimura, Koichi; Tsukamoto, Kazuhiro; Kohno, Shigeru; Mukae, Hiroshi.
Afiliação
  • Hirayama T; Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Miyazaki T; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
  • Sumiyoshi M; Division of Respirology, Rheumatology, Infectious Diseases, and Neurology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
  • Ito Y; Division of Respirology, Rheumatology, Infectious Diseases, and Neurology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
  • Ashizawa N; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
  • Takeda K; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
  • Iwanaga N; Infection Control and Education Center, Nagasaki University Hospital, Nagasaki, Japan.
  • Takazono T; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
  • Yamamoto K; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
  • Izumikawa K; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
  • Yanagihara K; Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Makimura K; Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
  • Tsukamoto K; Infection Control and Education Center, Nagasaki University Hospital, Nagasaki, Japan.
  • Kohno S; Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Mukae H; Department of Laboratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Antimicrob Agents Chemother ; 67(4): e0124322, 2023 04 18.
Article em En | MEDLINE | ID: mdl-36920237
ABSTRACT
Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin. Resistant C. auris with FKS1 mutations, including S639F, S639Y, D642Y, R1354H, or R1354Y, were isolated and found to be micafungin- and caspofungin-resistant in vivo; however, the MICs of isolates with mutation in R1354 remained below the micafungin breakpoint in vitro.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Equinocandinas / Candida auris Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Equinocandinas / Candida auris Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article