Your browser doesn't support javascript.
loading
Immune response and protective efficacy of mannosylated polyethylenimine (PEI) as an antigen delivery vector, administered with a Streptococcus agalactiae DNA vaccine in Nile tilapia (Oreochromis niloticus).
Chen, Xin-Jin; Huang, Man-Yu; Wangkahart, Eakapol; Cai, Jia; Huang, Yu; Jian, Ji-Chang; Wang, Bei.
Afiliação
  • Chen XJ; Guangdong Ocean University, College of Fishery, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy culture, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang, PR China.
  • Huang MY; Guangdong Ocean University, College of Fishery, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy culture, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang, PR China.
  • Wangkahart E; Laboratory of Fish Immunology and Nutrigenomics, Applied Animal and Aquatic Sciences Research Unit, Division of Fisheries, Faculty of Technology, Mahasarakham University, Khamriang Sub-District, Kantarawichai, Mahasarakham, 44150, Thailand.
  • Cai J; Guangdong Ocean University, College of Fishery, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy culture, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang, PR China; Southern Marine Science and Engineering G
  • Huang Y; Guangdong Ocean University, College of Fishery, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy culture, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang, PR China; Southern Marine Science and Engineering G
  • Jian JC; Guangdong Ocean University, College of Fishery, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy culture, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang, PR China; Southern Marine Science and Engineering G
  • Wang B; Guangdong Ocean University, College of Fishery, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy culture, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang, PR China; Southern Marine Science and Engineering G
Fish Shellfish Immunol ; 135: 108684, 2023 Apr.
Article em En | MEDLINE | ID: mdl-36921882
ABSTRACT
This study examined the effectiveness of a DNA vaccine for S. agalactiae that was delivered by mannose-based polyethyleneimine (Man-PEI). The results showed that Man-PEI/pcDNA-Sip stimulated a higher serum antibody titer compared to control or other vaccine groups (p < 0.05). Additionally, it induced higher expression of immune-related genes, and increased activities of superoxide dismutase (SOD), acid phosphatase (ACP) and alkaline phosphatase (AKP). Furthermore, the Man-PEI/pcDNA-Sip group showed an improved relative percent survival (RPS) of 85.71%. These results demonstrate the potential value of Man-PEI as a vaccine delivery vehicle, and suggest that it can be effective in boosting the immune protective rate induced by pcDNA-Sip vaccines.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estreptocócicas / Vacinas de DNA / Vacinas Estreptocócicas / Ciclídeos / Doenças dos Peixes Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estreptocócicas / Vacinas de DNA / Vacinas Estreptocócicas / Ciclídeos / Doenças dos Peixes Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article