The influence of serial 50 µL microsampling on rats administered azathioprine, the immunosuppressive drug.

Tanaka, Yoichi; Takahashi, Kazuaki; Hattori, Norimichi; Yokoyama, Hideaki; Yamaguchi, Koki; Shibui, Yusuke; Kawaguchi, Sayaka; Shimazaki, Taishi; Nakai, Keiko; Kusuhara, Hiroyuki; Saito, Yoshiro

The influence of serial 50 µL microsampling on rats administered azathioprine, the immunosuppressive drug.

Tanaka, Yoichi; Takahashi, Kazuaki; Hattori, Norimichi; Yokoyama, Hideaki; Yamaguchi, Koki; Shibui, Yusuke; Kawaguchi, Sayaka; Shimazaki, Taishi; Nakai, Keiko; Kusuhara, Hiroyuki; Saito, Yoshiro.

Afiliação

Tanaka Y; Division of Medicinal Safety Science, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kasasaki-shi, Kanagawa, Japan.
Takahashi K; LSIM Safety Institute Corporation., 14-1 Sunayama, Kamisu-shi, Ibaraki, Japan.
Hattori N; Ajinomoto Fine-Techno Co., Inc., 1-1, Suzuki-cho, Kawasaki-ku, Kwasaki-shi, Kanagawa, Japan.
Yokoyama H; Japan Tobacco Inc., 1-13-2, Fukuura, Kanazawa-ku, Yokohama-shi, Kanagawa, Japan.
Yamaguchi K; Japan Tobacco Inc., 1-13-2, Fukuura, Kanazawa-ku, Yokohama-shi, Kanagawa, Japan.
Shibui Y; Ajinomoto Fine-Techno Co., Inc., 1-1, Suzuki-cho, Kawasaki-ku, Kwasaki-shi, Kanagawa, Japan.
Kawaguchi S; Ajinomoto Fine-Techno Co., Inc., 1-1, Suzuki-cho, Kawasaki-ku, Kwasaki-shi, Kanagawa, Japan.
Shimazaki T; Japan Tobacco Inc., 1-13-2, Fukuura, Kanazawa-ku, Yokohama-shi, Kanagawa, Japan.
Nakai K; LSIM Safety Institute Corporation., 14-1 Sunayama, Kamisu-shi, Ibaraki, Japan.
Kusuhara H; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Saito Y; Division of Medicinal Safety Science, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kasasaki-shi, Kanagawa, Japan.

Toxicol Rep ; 10: 334-340, 2023.

Article em En | MEDLINE | ID: mdl-36923445

Palavras-chave

A/G, albumin/globulin; ALP, alkaline phosphatase; ALT, alanine transaminase; APTT, activated partial thromboplastin time; AST, aspartate transaminase; Azathioprine; BUN, blood urea nitrogen; CPK, creatine phosphokinase; Ca, calcium; Cl, chloride; Cre, creatinine; GLDH, glutamate dehydrogenase; Hematological parameter; ICH, International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use; Jugular vein; K, potassium; LDH, lactate dehydrogenase; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; Microsampling; Na, sodium; P, inorganic phosphorus; PT, prothrombin time; RBC, red blood cell; Rat; TK, toxicokinetics; Toxicokinetics; WBC, leukocyte/white blood cell; Î³GT, Î³-glutamyltranspeptidase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Ano de publicação: 2023 Tipo de documento: Article