Exposure to proton pump inhibitors and risk of diabetes: A systematic review and meta-analysis.
World J Diabetes
; 14(2): 120-129, 2023 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-36926660
ABSTRACT
BACKGROUND:
Exposure to proton pump inhibitors (PPIs) has been reported to have a potential role in the development of diabetes.AIM:
To determine the association between PPIs and diabetes.METHODS:
This meta-analysis is registered on PROSPERO (CRD42022352704). In August 2022, eligible studies were identified through a comprehensive literature search. In this study, odds ratios were combined with 95% confidence intervals using a random-effects model. The source of heterogeneity was assessed using sensitivity analysis and subgroup analysis. The publication bias was evaluated using Egger's test and Begg's test.RESULTS:
The meta-analysis included 9 studies with a total of 867185 participants. Results showed that the use of PPIs increased the risk of diabetes (odds ratio = 1.23, 95% confidence interval 1.05-1.43, n = 9, I2 = 96.3%). Subgroup analysis showed that geographic location and study type had significant effects on the overall results. Both Egger's and Begg's tests showed no publication bias (P > 0.05). Sensitivity analysis also confirmed the stability of the results.CONCLUSION:
The results of this study indicated that the use of PPIs was related to an increased risk of diabetes. However, more well-designed studies are needed to verify these results in the future.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article