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Hypoglycemic effect of Coffea arabica leaf extracts and major bioactive constituents.
Nascimento, G O; Marques, S P D; Maia, C E G; de Sousa, A F; Cunha, R L; Malta, M R; Owen, R W; Ferreira, M K A; da Silva, A W; Rebouças, E L; de Menezes, J E S A; Marinho, M M; Marinho, E S; Dos Santos, H S; Saliba, A S M C; Massarioli, A P; Alencar, S M; Sartori, A G O; Trevisan, M T S.
Afiliação
  • Nascimento GO; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
  • Marques SPD; Departamento de Química, Instituto Federal de Educação, Ciência e Tecnologia do Ceará, Quixadá, CE, Brazil.
  • Maia CEG; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
  • de Sousa AF; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
  • Cunha RL; Empresa de Pesquisa Agropecuária de Minas Gerais (EPAMIG), Belo Horizonte, MG, Brazil.
  • Malta MR; Empresa de Pesquisa Agropecuária de Minas Gerais (EPAMIG), Belo Horizonte, MG, Brazil.
  • Owen RW; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
  • Ferreira MKA; Postgraduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.
  • da Silva AW; Itaperi Campus, Laboratory of Natural Products Chemistry - LQPN-S, State University of Ceará, Science and Technology Center (CCT), Fortaleza, Ceará, Brazil.
  • Rebouças EL; Itaperi Campus, Laboratory of Natural Products Chemistry - LQPN-S, State University of Ceará, Science and Technology Center (CCT), Fortaleza, Ceará, Brazil.
  • de Menezes JESA; Northeast Biotechnology Network, Graduate Program of Biotechnology, State University of Ceará, Fortaleza, Ceará, Brazil.
  • Marinho MM; Northeast Biotechnology Network, Graduate Program of Biotechnology, State University of Ceará, Fortaleza, Ceará, Brazil.
  • Marinho ES; Itaperi Campus, Laboratory of Natural Products Chemistry - LQPN-S, State University of Ceará, Science and Technology Center (CCT), Fortaleza, Ceará, Brazil.
  • Dos Santos HS; Group of Theoretical Chemistry and Electrochemistry(GQTE), State University of Ceará, Limoeiro do Norte, CE, Brazil.
  • Saliba ASMC; Group of Theoretical Chemistry and Electrochemistry(GQTE), State University of Ceará, Limoeiro do Norte, CE, Brazil.
  • Massarioli AP; Center for Exact Sciences and Technology, Vale do Acarau State University, Sobral, CE, Brazil.
  • Alencar SM; Luiz de Queiroz College of Agriculture, Piracicaba, SP, Brazil.
  • Sartori AGO; Luiz de Queiroz College of Agriculture, Piracicaba, SP, Brazil.
  • Trevisan MTS; Luiz de Queiroz College of Agriculture, Piracicaba, SP, Brazil.
J Biomol Struct Dyn ; 41(24): 14871-14886, 2023.
Article em En | MEDLINE | ID: mdl-36927332
ABSTRACT
The present study focused on investigating the antioxidant, antiglycation activity, digestive enzymes inhibition, bioaccessibility and hypoglycemic effect of C. arabica leaves extracts. The extracts deactivated the O2•-, ROO•, H2O2, HOCl reactive oxygen species. Coffee leaves showed strong inhibition of α-glucosidase (IC50 = 40.30 µg mL-1) greater than the isolated metabolites and acarbose. There was also inhibition of pancreatic lipase (IC50 = 56.43 µg mL-1) in addition to a hypoglycemic effect in zebrafish similar to acarbose and metformin. With the exception of rutin, all biocompounds were detected at all stages of in vitro digestion. Finally, these results suggest that C. arabica leaf extracts possess antidiabetic and anti-obesity properties that can be attributed to the main metabolites and the synergistic action between them.Communicated by Ramaswamy H. Sarma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Coffea / Antioxidantes Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Coffea / Antioxidantes Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article