Hypoglycemic effect of Coffea arabica leaf extracts and major bioactive constituents.
J Biomol Struct Dyn
; 41(24): 14871-14886, 2023.
Article
em En
| MEDLINE
| ID: mdl-36927332
ABSTRACT
The present study focused on investigating the antioxidant, antiglycation activity, digestive enzymes inhibition, bioaccessibility and hypoglycemic effect of C. arabica leaves extracts. The extracts deactivated the O2â¢-, ROOâ¢, H2O2, HOCl reactive oxygen species. Coffee leaves showed strong inhibition of α-glucosidase (IC50 = 40.30 µg mL-1) greater than the isolated metabolites and acarbose. There was also inhibition of pancreatic lipase (IC50 = 56.43 µg mL-1) in addition to a hypoglycemic effect in zebrafish similar to acarbose and metformin. With the exception of rutin, all biocompounds were detected at all stages of in vitro digestion. Finally, these results suggest that C. arabica leaf extracts possess antidiabetic and anti-obesity properties that can be attributed to the main metabolites and the synergistic action between them.Communicated by Ramaswamy H. Sarma.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Coffea
/
Antioxidantes
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article