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Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.
Mu, Andre; Klare, William P; Baines, Sarah L; Ignatius Pang, C N; Guérillot, Romain; Harbison-Price, Nichaela; Keller, Nadia; Wilksch, Jonathan; Nhu, Nguyen Thi Khanh; Phan, Minh-Duy; Keller, Bernhard; Nijagal, Brunda; Tull, Dedreia; Dayalan, Saravanan; Chua, Hwa Huat Charlie; Skoneczny, Dominik; Koval, Jason; Hachani, Abderrahman; Shah, Anup D; Neha, Nitika; Jadhav, Snehal; Partridge, Sally R; Cork, Amanda J; Peters, Kate; Bertolla, Olivia; Brouwer, Stephan; Hancock, Steven J; Álvarez-Fraga, Laura; De Oliveira, David M P; Forde, Brian; Dale, Ashleigh; Mujchariyakul, Warasinee; Walsh, Calum J; Monk, Ian; Fitzgerald, Anna; Lum, Mabel; Correa-Ospina, Carolina; Roy Chowdhury, Piklu; Parton, Robert G; De Voss, James; Beckett, James; Monty, Francois; McKinnon, Jessica; Song, Xiaomin; Stephen, John R; Everest, Marie; Bellgard, Matt I; Tinning, Matthew; Leeming, Michael; Hocking, Dianna.
Afiliação
  • Mu A; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Klare WP; Wellcome Sanger Institute, Hinxton, UK.
  • Baines SL; Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.
  • Ignatius Pang CN; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Guérillot R; Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.
  • Harbison-Price N; Bioinformatics Group, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
  • Keller N; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Wilksch J; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Nhu NTK; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
  • Phan MD; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Keller B; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Nijagal B; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Tull D; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
  • Dayalan S; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Chua HHC; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
  • Skoneczny D; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Koval J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
  • Hachani A; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia.
  • Shah AD; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia.
  • Neha N; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia.
  • Jadhav S; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia.
  • Partridge SR; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia.
  • Cork AJ; Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.
  • Peters K; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Bertolla O; Monash Proteomics and Metabolomics Facility, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.
  • Brouwer S; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia.
  • Hancock SJ; Metabolomics Australia, Bio21 Institute, The University of Melbourne, Melbourne, Australia.
  • Álvarez-Fraga L; Centre for Infectious Diseases and Microbiology, Westmead Hospital/ Westmead Institute, and Sydney ID, University of Sydney, Sydney, NSW, Australia.
  • De Oliveira DMP; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Forde B; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
  • Dale A; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Mujchariyakul W; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
  • Walsh CJ; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Monk I; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
  • Fitzgerald A; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Lum M; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
  • Correa-Ospina C; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Roy Chowdhury P; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Parton RG; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • De Voss J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
  • Beckett J; Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Monty F; Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.
  • McKinnon J; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Song X; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Stephen JR; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Everest M; Bioplatforms Australia Ltd., Sydney, NSW, Australia.
  • Bellgard MI; Bioplatforms Australia Ltd., Sydney, NSW, Australia.
  • Tinning M; Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.
  • Leeming M; Australian Institute for Microbiology and Infection, University of Technology Sydney, Sydney, NSW, Australia.
  • Hocking D; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Nat Commun ; 14(1): 1530, 2023 03 18.
Article em En | MEDLINE | ID: mdl-36934086
ABSTRACT
Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20-40%, with antibiotic resistance dramatically increasing this mortality risk. To develop a reference dataset enabling the identification of common bacterial targets for therapeutic intervention, we applied a standardized genomic, transcriptomic, proteomic and metabolomic technological framework to multiple clinical isolates of four sepsis-causing pathogens Escherichia coli, Klebsiella pneumoniae species complex, Staphylococcus aureus and Streptococcus pyogenes. Exposure to human serum generated a sepsis molecular signature containing global increases in fatty acid and lipid biosynthesis and metabolism, consistent with cell envelope remodelling and nutrient adaptation for osmoprotection. In addition, acquisition of cholesterol was identified across the bacterial species. This detailed reference dataset has been established as an open resource to support discovery and translational research.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Sepse Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Sepse Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article