Genetic hyperactivation of Nrf2 causes larval lethality in Keap1a and Keap1b-double-knockout zebrafish.

Bian, Lixuan; Nguyen, Vu Thanh; Tamaoki, Junya; Endo, Yuka; Dong, Guilin; Sato, Ayaka; Kobayashi, Makoto

Bian, Lixuan; Nguyen, Vu Thanh; Tamaoki, Junya; Endo, Yuka; Dong, Guilin; Sato, Ayaka; Kobayashi, Makoto.

Afiliação

Bian L; Department of Molecular and Developmental Biology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.
Nguyen VT; Department of Molecular and Developmental Biology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan; Division of Aquaculture Biotechnology, Biotechnology Center of Ho Chi Minh City, Ho Chi Minh City, Viet Nam.
Tamaoki J; Department of Molecular and Developmental Biology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.
Endo Y; Department of Molecular and Developmental Biology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.
Dong G; Department of Molecular and Developmental Biology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.
Sato A; Department of Molecular and Developmental Biology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.
Kobayashi M; Department of Molecular and Developmental Biology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan. Electronic address: makobayash@md.tsukuba.ac.jp.

Redox Biol ; 62: 102673, 2023 06.

Article em En | MEDLINE | ID: mdl-36934645

Assuntos

Fator 2 Relacionado a NF-E2; Peixe-Zebra; Animais; Animais Geneticamente Modificados; Proteínas de Transporte/metabolismo; Técnicas de Inativação de Genes; Proteína 1 Associada a ECH Semelhante a Kelch/genética; Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo; Larva/genética; Mamíferos/metabolismo; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; Estresse Oxidativo; Peixe-Zebra/genética; Peixe-Zebra/metabolismo; Proteínas de Peixe-Zebra/genética; Proteínas de Peixe-Zebra/metabolismo

Palavras-chave

Eating defects; Keap1Nrf2 pathway; Nrf2-inhibiting compounds; Visual cycle genes; keap1a;keap1b-double knockout zebrafish

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Fator 2 Relacionado a NF-E2 Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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