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Using multivariate nonlinear mixed-effects model to investigate factors influencing symptom improvement after high tibial osteotomy in combination with bone marrow concentrate injection for medial compartment knee osteoarthritis: a prospective, open-label study.
Cheng, Hsiao-Yi; Liang, Chun-Wei; Chu, Chen-Lun; Hsu, Hao-Wei; Hou, Sheng-Mou; Shih, Kao-Shang.
Afiliação
  • Cheng HY; Department of Primary Care Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
  • Liang CW; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
  • Chu CL; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
  • Hsu HW; Department of Orthopaedic Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
  • Hou SM; Department of Orthopaedic Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
  • Shih KS; Department of Orthopaedic Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
BMC Musculoskelet Disord ; 24(1): 208, 2023 Mar 20.
Article em En | MEDLINE | ID: mdl-36941604
PURPOSE: To investigate the effects of various demographic, structural, radiographic, and clinical factors on the prognosis of patients with medial compartmental knee osteoarthritis with varus deformity undergoing medial opening wedge high tibial osteotomy (HTO) in combination with bone marrow concentrate (BMC) injection. METHODS: In this prospective study, 20 patients underwent medial opening wedge HTO in combination with BMC injection with 12 months of follow-up. The structural and radiographic outcomes were evaluated by femorotibial angle and posterior tibial slope angle. The clinical outcomes were evaluated by visual analogue scale (VAS), Western Ontario and McMaster Universities Arthritis Index (WOMAC), and The Knee injury and Osteoarthritis Outcome Score (KOOS). Multivariate nonlinear mixed-effects models with asymptotic regressions were used to model the trajectory of symptom improvement. RESULTS: Medial opening wedge HTO in combination with BMC corrected the malalignment of the knee and led to significant symptom relief. The improvement of clinical symptoms reached a plateau 6 months after the surgery. Greater symptom severity at baseline and lower Kellgren-Lawrance (KL) grades were correlated with better post-operative clinical outcomes. Body-Mass-Index (BMI), femorotibial angle, age, and sex may also play a role in influencing the extent of symptom relief. CONCLUSION: Symptom severity at baseline is important for prognosis prediction. In clinical practice, we suggest that the evaluation of clinical features and functional status of the patients be more emphasised.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite do Joelho Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite do Joelho Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article