The Underappreciated Role of Secretory IgA in IBD.

Loss of immune tolerance to bacterial antigens represents the likely trigger of the dysregulated immune response that characterizes IBD, yet the interface between B cells, IgA, and the microbiota during initiation and progression of disease has been understudied. Here we review important aspects of the biology of IgA, its role on the control of the microbiota in mouse models, and its potential role on the pathogenesis of IBD.