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PIK3CA mutations and their impact on survival outcomes of patients with endometrial cancer: A systematic review and meta-analysis.
Bredin, Hanna K; Krakstad, Camilla; Hoivik, Erling A.
Afiliação
  • Bredin HK; Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway.
  • Krakstad C; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
  • Hoivik EA; Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway.
PLoS One ; 18(3): e0283203, 2023.
Article em En | MEDLINE | ID: mdl-36943861
Several studies have highlighted the frequent alterations of the PI3K pathway in endometrial cancer leading to increased signaling activation with potential for targeted treatment. The objective of this meta-study was to evaluate how PIK3CA exon 9/20 mutations affect survival in endometrial cancer patients, based on available literature. Topic-based search strategies were applied to databases including CENTRAL, MEDLINE, Embase, Web of Science and COSMIC. All studies assessing the impact of mutations in exon 9 and exon 20 of PIK3CA on survival rates of endometrial cancer patients were selected for inclusion. Statistical meta-analysis was performed with the 'meta' package in RStudio. Overall, 7 of 612 screened articles were included in the present study, comprising 1098 women with endometrial cancer. Meta-analysis revealed a tendency of impaired survival for patients with PIK3CA exon 9 and/or exon 20 mutations (RR 1.28; 95% CI 0.84, 1.94; p = 0.25). This tendency was consistent in subgroup analyses stratified by histologic type or -grade, with the most prominent effect in low-grade endometrial cancers (RR 2.04; 95% CI 0.90, 4.62; p = 0.09). In summary, these results suggest that PIK3CA mutations negatively influence survival outcomes of patients with endometrial cancer, including those with low-grade tumors.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Fosfatidilinositol 3-Quinases Tipo de estudo: Systematic_reviews Limite: Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Fosfatidilinositol 3-Quinases Tipo de estudo: Systematic_reviews Limite: Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article