HIF-1&#945;-induced upregulated miR-322 forms a feedback loop by targeting Smurf2 and Smad7 to activate Smad3/ß-catenin/HIF-1&#945;, thereby improving myocardial ischemia-reperfusion injury.

Dong, Wei; Dong, Chen; Zhu, Jianbing; Zheng, Yaofu; Weng, Junfei; Liu, Leilei; Ruan, Yang; Fang, Xu; Chen, Jin; Liu, Wenyu; Peng, Xiaoping; Chen, Xuanying

HIF-1α-induced upregulated miR-322 forms a feedback loop by targeting Smurf2 and Smad7 to activate Smad3/ß-catenin/HIF-1α, thereby improving myocardial ischemia-reperfusion injury.

Dong, Wei; Dong, Chen; Zhu, Jianbing; Zheng, Yaofu; Weng, Junfei; Liu, Leilei; Ruan, Yang; Fang, Xu; Chen, Jin; Liu, Wenyu; Peng, Xiaoping; Chen, Xuanying.

Afiliação

Dong W; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Dong C; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zhu J; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zheng Y; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Weng J; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Liu L; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Ruan Y; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Fang X; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Chen J; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Liu W; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Peng X; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Chen X; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Cell Biol Int ; 47(5): 894-906, 2023 May.

Article em En | MEDLINE | ID: mdl-36950834

Assuntos

MicroRNAs; Infarto do Miocárdio; Traumatismo por Reperfusão Miocárdica; Humanos; Apoptose; beta Catenina/metabolismo; Retroalimentação; MicroRNAs/metabolismo; Infarto do Miocárdio/genética; Traumatismo por Reperfusão Miocárdica/metabolismo; Miócitos Cardíacos/metabolismo; Proteína Smad3/metabolismo; Proteína Smad7/metabolismo; Ubiquitina-Proteína Ligases/metabolismo; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo

Palavras-chave

HIF-1α; Smad7; Smurf2; miR-322; myocardial ischemia/reperfusion injury; positive feedback loop; the Smad3/ß-catenin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão Miocárdica / MicroRNAs / Infarto do Miocárdio Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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