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Polycystic ovary syndrome is associated with a higher risk of premalignant and malignant endometrial polyps in premenopausal women: a retrospective study in a tertiary teaching hospital.
Lu, Ling; Luo, Jianbo; Deng, Jie; Huang, Chaolin; Li, Chanyu.
Afiliação
  • Lu L; Department of Gynaecology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China.
  • Luo J; Department of Gynaecology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China.
  • Deng J; Department of Gynaecology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China.
  • Huang C; Department of Gynaecology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China. 277740484@qq.com.
  • Li C; Department of Gynaecology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China. 516476638@qq.com.
BMC Womens Health ; 23(1): 127, 2023 03 24.
Article em En | MEDLINE | ID: mdl-36964546
BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by anovulation, insufficient progesterone, hyperandrogenism, and insulin resistance. These factors can disrupt the endometrium of PCOS patients and can lead to chronic low-grade inflammation in the endometrium, endometrial hyperplasia, or even endometrial cancer. OBJECTIVE: The aim of this study was to investigate the prevalence of premalignant and malignant endometrial polyps in premenopausal women and to further explore whether PCOS is associated with premalignant and malignant changes in endometrial polyps. METHODS: This study was conducted by retrieving the medical data of 4236 premenopausal women who underwent hysteroscopic polypectomies between January 2015 and December 2021. Demographic and clinical data regarding age, height, weight, parity, hormone replacement therapy, oral contraceptives, abnormal uterine bleeding, hypertension, diabetes mellitus, PCOS, number of polyps, and size of polyps were collected, and their associations with premalignant and malignant changes in endometrial polyps were analysed. RESULT: Among the endometrial polyps removed by hysteroscopic polypectomy in premenopausal women, the prevalence of premalignant and malignant polyps was 2.15%, which comprised hyperplasia with atypia at 1.13% and endometrial carcinoma at 1.02%. PCOS was associated with a higher risk of premalignant and malignant endometrial polyps in premenopausal women after adjustment for potential confounding factors. CONCLUSION: PCOS is associated with a higher risk of premalignant and malignant endometrial polyps in premenopausal women. Therefore, it is important to evaluate the endometrium in PCOS patients with ultrasonography or hysteroscopy, and active management involving hysteroscopic polypectomy should be offered to PCOS patients diagnosed with endometrial polyps regardless of symptoms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Pólipos / Lesões Pré-Cancerosas / Doenças Uterinas / Neoplasias Uterinas / Neoplasias do Endométrio Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Pregnancy Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Pólipos / Lesões Pré-Cancerosas / Doenças Uterinas / Neoplasias Uterinas / Neoplasias do Endométrio Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Pregnancy Idioma: En Ano de publicação: 2023 Tipo de documento: Article