Your browser doesn't support javascript.
loading
Integrative proteogenomic characterization of early esophageal cancer.
Li, Lingling; Jiang, Dongxian; Zhang, Qiao; Liu, Hui; Xu, Fujiang; Guo, Chunmei; Qin, Zhaoyu; Wang, Haixing; Feng, Jinwen; Liu, Yang; Chen, Weijie; Zhang, Xue; Bai, Lin; Tian, Sha; Tan, Subei; Xu, Chen; Song, Qi; Liu, Yalan; Zhong, Yunshi; Chen, Tianyin; Zhou, Pinghong; Zhao, Jian-Yuan; Hou, Yingyong; Ding, Chen.
Afiliação
  • Li L; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Jiang D; Department of Pathology, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
  • Zhang Q; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Liu H; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Xu F; Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
  • Guo C; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Qin Z; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Wang H; Department of Pathology, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
  • Feng J; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Liu Y; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Chen W; Department of Pathology, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
  • Zhang X; Department of Pathology, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
  • Bai L; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Tian S; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Tan S; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Xu C; Department of Pathology, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
  • Song Q; Department of Pathology, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
  • Liu Y; Department of Pathology, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
  • Zhong Y; Department of Pathology, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
  • Chen T; Department of Pathology, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
  • Zhou P; Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University, Shanghai, 200032, China. zhou.pinghong@zs-hospital.sh.cn.
  • Zhao JY; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai, 200433, China. zhaojy@fudan.edu.cn.
  • Hou Y; Institute for Development and Regenerative Cardiovascular Medicine, MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. zhaojy@fudan.edu.cn.
  • Ding C; Department of Anatomy and Neuroscience Research Institute , School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China. zhaojy@fudan.edu.cn.
Nat Commun ; 14(1): 1666, 2023 03 25.
Article em En | MEDLINE | ID: mdl-36966136
ABSTRACT
Esophageal squamous cell carcinoma (ESCC) is malignant while the carcinogenesis is still unclear. Here, we perform a comprehensive multi-omics analysis of 786 trace-tumor-samples from 154 ESCC patients, covering 9 histopathological stages and 3 phases. Proteogenomics elucidates cancer-driving waves in ESCC progression, and reveals the molecular characterization of alcohol drinking habit associated signatures. We discover chromosome 3q gain functions in the transmit from nontumor to intraepithelial neoplasia phases, and find TP53 mutation enhances DNA replication in intraepithelial neoplasia phase. The mutations of AKAP9 and MCAF1 upregulate glycolysis and Wnt signaling, respectively, in advanced-stage ESCC phase. Six major tracks related to different clinical features during ESCC progression are identified, which is validated by an independent cohort with another 256 samples. Hyperphosphorylated phosphoglycerate kinase 1 (PGK1, S203) is considered as a drug target in ESCC progression. This study provides insight into the understanding of ESCC molecular mechanism and the development of therapeutic targets.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Carcinoma de Células Escamosas / Proteogenômica / Carcinoma de Células Escamosas do Esôfago Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Carcinoma de Células Escamosas / Proteogenômica / Carcinoma de Células Escamosas do Esôfago Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article