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Cocktail-party listening and cognitive abilities show strong pleiotropy.
Mathias, Samuel R; Knowles, Emma E M; Mollon, Josephine; Rodrigue, Amanda L; Woolsey, Mary K; Hernandez, Alyssa M; Garret, Amy S; Fox, Peter T; Olvera, Rene L; Peralta, Juan M; Kumar, Satish; Göring, Harald H H; Duggirala, Ravi; Curran, Joanne E; Blangero, John; Glahn, David C.
Afiliação
  • Mathias SR; Department of Psychiatry, Boston Children's Hospital, Boston, MA, United States.
  • Knowles EEM; Harvard Medical School, Boston, MA, United States.
  • Mollon J; Department of Psychiatry, Boston Children's Hospital, Boston, MA, United States.
  • Rodrigue AL; Harvard Medical School, Boston, MA, United States.
  • Woolsey MK; Department of Psychiatry, Boston Children's Hospital, Boston, MA, United States.
  • Hernandez AM; Harvard Medical School, Boston, MA, United States.
  • Garret AS; Department of Psychiatry, Boston Children's Hospital, Boston, MA, United States.
  • Fox PT; Harvard Medical School, Boston, MA, United States.
  • Olvera RL; Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, United States.
  • Peralta JM; Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, United States.
  • Kumar S; Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, United States.
  • Göring HHH; Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, United States.
  • Duggirala R; South Texas Veterans Health Care System, San Antonio, TX, United States.
  • Curran JE; Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, United States.
  • Blangero J; Department of Human Genetics, South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, United States.
  • Glahn DC; Department of Human Genetics, South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, United States.
Front Neurol ; 14: 1071766, 2023.
Article em En | MEDLINE | ID: mdl-36970519
ABSTRACT

Introduction:

The cocktail-party problem refers to the difficulty listeners face when trying to attend to relevant sounds that are mixed with irrelevant ones. Previous studies have shown that solving these problems relies on perceptual as well as cognitive processes. Previously, we showed that speech-reception thresholds (SRTs) on a cocktail-party listening task were influenced by genetic factors. Here, we estimated the degree to which these genetic factors overlapped with those influencing cognitive abilities.

Methods:

We measured SRTs and hearing thresholds (HTs) in 493 listeners, who ranged in age from 18 to 91 years old. The same individuals completed a cognitive test battery comprising 18 measures of various cognitive domains. Individuals belonged to large extended pedigrees, which allowed us to use variance component models to estimate the narrow-sense heritability of each trait, followed by phenotypic and genetic correlations between pairs of traits.

Results:

All traits were heritable. The phenotypic and genetic correlations between SRTs and HTs were modest, and only the phenotypic correlation was significant. By contrast, all genetic SRT-cognition correlations were strong and significantly different from 0. For some of these genetic correlations, the hypothesis of complete pleiotropy could not be rejected.

Discussion:

Overall, the results suggest that there was substantial genetic overlap between SRTs and a wide range of cognitive abilities, including abilities without a major auditory or verbal component. The findings highlight the important, yet sometimes overlooked, contribution of higher-order processes to solving the cocktail-party problem, raising an important caveat for future studies aiming to identify specific genetic factors that influence cocktail-party listening.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article