Cannabinoid type 2 receptor activation inhibits MPP<sup>+</sup>-induced M1 differentiation of microglia through activating PI3K/Akt/Nrf2 signal pathway.

Wang, Mengya; Liu, Man; Ma, Zegang

Cannabinoid type 2 receptor activation inhibits MPP⁺-induced M1 differentiation of microglia through activating PI3K/Akt/Nrf2 signal pathway.

Wang, Mengya; Liu, Man; Ma, Zegang.

Afiliação

Wang M; Department of Physiology, School of Basic Medicine, Institute of Brain Science and Disorders, Qingdao University, Qingdao, 266071, China.
Liu M; Department of Physiology, School of Basic Medicine, Institute of Brain Science and Disorders, Qingdao University, Qingdao, 266071, China.
Ma Z; Department of Physiology, School of Basic Medicine, Institute of Brain Science and Disorders, Qingdao University, Qingdao, 266071, China. mazegang@126.com.

Mol Biol Rep ; 50(5): 4423-4433, 2023 May.

Article em En | MEDLINE | ID: mdl-36977807

Assuntos

Canabinoides; Microglia; Humanos; Microglia/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Fator 2 Relacionado a NF-E2/metabolismo; 1-Metil-4-fenilpiridínio/farmacologia; 1-Metil-4-fenilpiridínio/metabolismo; Fosfatidilinositol 3-Quinase/metabolismo; Doenças Neuroinflamatórias; Receptor CB2 de Canabinoide/genética; Transdução de Sinais; Canabinoides/farmacologia; Canabinoides/metabolismo

Palavras-chave

Cannabinoid type 2 receptor; JWH133; M1/M2 transformation; Microglia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canabinoides / Microglia Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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